1ix5: Difference between revisions

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[[Image:1ix5.~~jpg~~|left|200px]]

[[Image:1ix5.png|left|200px]]

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~~'''~~Solution structure of the Methanococcus thermolithotrophicus FKBP~~'''~~

===Solution structure of the Methanococcus thermolithotrophicus FKBP===

~~==Overview==~~

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~~Here we report the solution structure of an archaeal FK506-binding protein (FKBP) from a thermophilic archaeum~~, ~~Methanococcus thermolithotrophicus (MtFKBP17), which has peptidyl prolyl cis-trans isomerase (PPIase) and chaperone-like activities~~, to ~~reveal~~ the ~~structural basis for the dual function~~. ~~In addition to a typical PPIase domain~~, ~~a newly identified domain~~ is ~~formed in~~ the ~~flap loop by a 48-residue insert that is required for the chaperone-like activity~~. ~~The new domain, called IF domain (the Insert in the Flap), is a novel~~-~~folding motif and exposes a hydrophobic surface, which we consider to play an important role in the chaperone~~-~~like activity.~~

The line below this paragraph, {{ABSTRACT_PUBMED_12729748}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 12729748 is the PubMed ID number.

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==About this Structure==

1IX5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Methanothermococcus_thermolithotrophicus Methanothermococcus thermolithotrophicus]. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IX5 OCA].

1IX5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Methanothermococcus_thermolithotrophicus Methanothermococcus thermolithotrophicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IX5 OCA].

==Reference==

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[[Category: Fkbp fold]]

[[Category: Ppiase]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May~~ ~~2 20~~:31:54 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 14:09:27 2008''

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-[[Image:1ix5.jpg|left|200px]]
+{{Seed}}
+[[Image:1ix5.png|left|200px]]
 <!--
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 {{STRUCTURE_1ix5|  PDB=1ix5  |  SCENE=  }}
-'''Solution structure of the Methanococcus thermolithotrophicus FKBP'''
+===Solution structure of the Methanococcus thermolithotrophicus FKBP===
-==Overview==
+<!--
-Here we report the solution structure of an archaeal FK506-binding protein (FKBP) from a thermophilic archaeum, Methanococcus thermolithotrophicus (MtFKBP17), which has peptidyl prolyl cis-trans isomerase (PPIase) and chaperone-like activities, to reveal the structural basis for the dual function. In addition to a typical PPIase domain, a newly identified domain is formed in the flap loop by a 48-residue insert that is required for the chaperone-like activity. The new domain, called IF domain (the Insert in the Flap), is a novel-folding motif and exposes a hydrophobic surface, which we consider to play an important role in the chaperone-like activity.
+The line below this paragraph, {{ABSTRACT_PUBMED_12729748}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 12729748 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_12729748}}
 ==About this Structure==
-IX5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Methanothermococcus_thermolithotrophicus Methanothermococcus thermolithotrophicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IX5 OCA].
+IX5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Methanothermococcus_thermolithotrophicus Methanothermococcus thermolithotrophicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IX5 OCA].
 ==Reference==
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 [[Category: Fkbp fold]]
 [[Category: Ppiase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 20:31:54 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 14:09:27 2008''