1j7d: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
Line 1: Line 1:
[[Image:1j7d.jpg|left|200px]]
{{Seed}}
[[Image:1j7d.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1j7d|  PDB=1j7d  |  SCENE=  }}  
{{STRUCTURE_1j7d|  PDB=1j7d  |  SCENE=  }}  


'''Crystal Structure of hMms2-hUbc13'''
===Crystal Structure of hMms2-hUbc13===




==Overview==
<!--
The ubiquitin conjugating enzyme complex Mms2-Ubc13 plays a key role in post-replicative DNA repair in yeast and the NF-kappaB signal transduction pathway in humans. This complex assembles novel polyubiquitin chains onto yet uncharacterized protein targets. Here we report the crystal structure of a complex between hMms2 (Uev1) and hUbc13 at 1.85 A resolution and a structure of free hMms2 at 1.9 A resolution. These structures reveal that the hMms2 monomer undergoes a localized conformational change upon interaction with hUbc13. The nature of the interface provides a physical basis for the preference of Mms2 for Ubc13 as a partner over a variety of other structurally similar ubiquitin-conjugating enzymes. The structure of the hMms2-hUbc13 complex provides the conceptual foundation for understanding the mechanism of Lys 63 multiubiquitin chain assembly and for its interactions with the RING finger proteins Rad5 and Traf6.
The line below this paragraph, {{ABSTRACT_PUBMED_11473255}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 11473255 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_11473255}}


==About this Structure==
==About this Structure==
Line 35: Line 39:
[[Category: Ubc]]
[[Category: Ubc]]
[[Category: Ubiquitin]]
[[Category: Ubiquitin]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:52:26 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 14:34:56 2008''

Revision as of 11:34, 1 July 2008

File:1j7d.png

Template:STRUCTURE 1j7d

Crystal Structure of hMms2-hUbc13

Template:ABSTRACT PUBMED 11473255

About this Structure

1J7D is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the human ubiquitin conjugating enzyme complex, hMms2-hUbc13., Moraes TF, Edwards RA, McKenna S, Pastushok L, Xiao W, Glover JN, Ellison MJ, Nat Struct Biol. 2001 Aug;8(8):669-73. PMID:11473255

Page seeded by OCA on Tue Jul 1 14:34:56 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=1j7d&oldid=615181"