1jes: Difference between revisions

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[[Image:1jes.gif|left|200px]]
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{{STRUCTURE_1jes|  PDB=1jes  |  SCENE=  }}  
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'''Crystal Structure of a Copper-Mediated Base Pair in DNA'''
===Crystal Structure of a Copper-Mediated Base Pair in DNA===




==Overview==
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Stable and selective DNA base pairing by metal coordination was recently demonstrated with nucleotides containing complementary pyridine-2,6-dicarboxylate (Dipic) and pyridine (Py) bases (Meggers, E.; Holland, P. L.; Tolman; W. B.; Romesberg, F. E.; Schultz, P. G. J. Am. Chem. Soc. 2000, 122, 10714-10715). To understand the structural consequences of introducing this novel base pair into DNA we have solved the crystal structure of a duplex containing the metallo-base pair. The structure shows that the bases pair as designed, but in a Z-DNA conformation. The structure also provides a structural explanation for the B- to Z-DNA transition in this duplex. Further solution studies demonstrate that the metallo-base pair is compatible with Z- or B-DNA conformations, depending on the duplex sequence.
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{{ABSTRACT_PUBMED_11734038}}


==About this Structure==
==About this Structure==
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[[Category: Unnatural]]
[[Category: Unnatural]]
[[Category: Z-dna]]
[[Category: Z-dna]]
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Revision as of 17:08, 1 July 2008

File:1jes.png

Template:STRUCTURE 1jes

Crystal Structure of a Copper-Mediated Base Pair in DNA

Template:ABSTRACT PUBMED 11734038

About this Structure

Full crystallographic information is available from OCA.

Reference

Structure of a copper-mediated base pair in DNA., Atwell S, Meggers E, Spraggon G, Schultz PG, J Am Chem Soc. 2001 Dec 12;123(49):12364-7. PMID:11734038

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