1jf9: Difference between revisions

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[[Image:1jf9.gif|left|200px]]
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[[Image:1jf9.png|left|200px]]


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{{STRUCTURE_1jf9|  PDB=1jf9  |  SCENE=  }}  
{{STRUCTURE_1jf9|  PDB=1jf9  |  SCENE=  }}  


'''Crystal Structure of selenocysteine lyase'''
===Crystal Structure of selenocysteine lyase===




==Overview==
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The Escherichia coli NifS CsdB protein is a member of the homodimeric pyridoxal 5'-phosphate (PLP)-dependent family of enzymes. These enzymes are capable of decomposing cysteine or selenocysteine into L-alanine and sulfur or selenium, respectively. E. coli NifS CsdB has a high specificity for L-selenocysteine in comparison to l-cysteine, suggesting a role for this enzyme is selenium metabolism. The 2.0 A crystal structure of E. coli NifS CsdB reveals a high-resolution view of the active site of this enzyme in apo-, persulfide, perselenide, and selenocysteine-bound intermediates, suggesting a mechanism for the stabilization of the enzyme persulfide and perselenide intermediates during catalysis, a necessary intermediate in the formation of sulfur and selenium containing metabolites.
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{{ABSTRACT_PUBMED_11827487}}


==About this Structure==
==About this Structure==
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[[Category: Selenocysteine]]
[[Category: Selenocysteine]]
[[Category: Structural genomic]]
[[Category: Structural genomic]]
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Revision as of 17:09, 1 July 2008

File:1jf9.png

Template:STRUCTURE 1jf9

Crystal Structure of selenocysteine lyase

Template:ABSTRACT PUBMED 11827487

About this Structure

1JF9 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Analysis of the E. coli NifS CsdB protein at 2.0 A reveals the structural basis for perselenide and persulfide intermediate formation., Lima CD, J Mol Biol. 2002 Feb 1;315(5):1199-208. PMID:11827487

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