1jg5: Difference between revisions

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[[Image:1jg5.jpg|left|200px]]
{{Seed}}
[[Image:1jg5.png|left|200px]]


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{{STRUCTURE_1jg5|  PDB=1jg5  |  SCENE=  }}  
{{STRUCTURE_1jg5|  PDB=1jg5  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF RAT GTP CYCLOHYDROLASE I FEEDBACK REGULATORY PROTEIN, GFRP'''
===CRYSTAL STRUCTURE OF RAT GTP CYCLOHYDROLASE I FEEDBACK REGULATORY PROTEIN, GFRP===




==Overview==
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Tetrahydrobiopterin, the cofactor required for hydroxylation of aromatic amino acids regulates its own synthesis in mammals through feedback inhibition of GTP cyclohydrolase I. This mechanism is mediated by a regulatory subunit called GTP cyclohydrolase I feedback regulatory protein (GFRP). The 2.6 A resolution crystal structure of rat GFRP shows that the protein forms a pentamer. This indicates a model for the interaction of mammalian GTP cyclohydrolase I with its regulator, GFRP. Kinetic investigations of human GTP cyclohydrolase I in complex with rat and human GFRP showed similar regulatory effects of both GFRP proteins.
The line below this paragraph, {{ABSTRACT_PUBMED_11580249}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_11580249}}


==About this Structure==
==About this Structure==
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[[Category: Alpha/beta structure]]
[[Category: Alpha/beta structure]]
[[Category: Beta sheet]]
[[Category: Beta sheet]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:11:08 2008''
 
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