1jgg: Difference between revisions

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[[Image:1jgg.gif|left|200px]]
{{Seed}}
[[Image:1jgg.png|left|200px]]


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{{STRUCTURE_1jgg|  PDB=1jgg  |  SCENE=  }}  
{{STRUCTURE_1jgg|  PDB=1jgg  |  SCENE=  }}  


'''Even-skipped Homeodomain Complexed to AT-rich DNA'''
===Even-skipped Homeodomain Complexed to AT-rich DNA===




==Overview==
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even-skipped is a homeobox gene important in controlling segment patterning in the embryonic fruit fly. Its homeobox encodes a DNA binding domain which binds with similar affinities to two DNA consensus sequences, one AT-rich, the other GC-rich. We describe a crystallographic analysis of the Even-skipped homeodomain complexed to an AT-rich oligonucleotide at 2.0 A resolution. The structure reveals a novel arrangement of two homeodomains bound to one 10 bp DNA sequence in a tandem fashion. This arrangement suggests a mechanism for the homeoproteins' regulatory specificity. In addition, the functionally important residue Gln50 is observed in multiple conformations making direct and water-mediated hydrogen bonds with the DNA bases.
The line below this paragraph, {{ABSTRACT_PUBMED_8557047}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_8557047}}


==About this Structure==
==About this Structure==
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[[Category: Homeodomain]]
[[Category: Homeodomain]]
[[Category: Protein-dna complex]]
[[Category: Protein-dna complex]]
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