1jht: Difference between revisions

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[[Image:1jht.gif|left|200px]]
{{Seed}}
[[Image:1jht.png|left|200px]]


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{{STRUCTURE_1jht|  PDB=1jht  |  SCENE=  }}  
{{STRUCTURE_1jht|  PDB=1jht  |  SCENE=  }}  


'''Crystal structure of HLA-A2*0201 in complex with a nonameric altered peptide ligand (ALGIGILTV) from the MART-1/Melan-A.'''
===Crystal structure of HLA-A2*0201 in complex with a nonameric altered peptide ligand (ALGIGILTV) from the MART-1/Melan-A.===




==Overview==
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We have determined high-resolution crystal structures of the complexes of HLA-A2 molecules with two modified immunodominant peptides from the melanoma tumor-associated protein Melan-A/Melanoma Ag recognized by T cells-1. The two peptides, a decamer and nonamer with overlapping sequences (ELAGIGILTV and ALGIGILTV), are modified in the second residue to increase their affinity for HLA-A2. The modified decamer is more immunogenic than the natural peptide and a candidate for peptide-based melanoma immunotherapy. The crystal structures at 1.8 and 2.15 A resolution define the differences in binding modes of the modified peptides, including different clusters of water molecules that appear to stabilize the peptide-HLA interaction. The structures suggest both how the wild-type peptides would bind and how three categories of cytotoxic T lymphocytes with differing fine specificity might recognize the two peptides.
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{{ABSTRACT_PUBMED_11544315}}


==About this Structure==
==About this Structure==
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[[Category: Tumor immunity]]
[[Category: Tumor immunity]]
[[Category: Vaccination]]
[[Category: Vaccination]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:14:19 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:16:02 2008''

Revision as of 17:16, 1 July 2008

File:1jht.png

Template:STRUCTURE 1jht

Crystal structure of HLA-A2*0201 in complex with a nonameric altered peptide ligand (ALGIGILTV) from the MART-1/Melan-A.

Template:ABSTRACT PUBMED 11544315

About this Structure

1JHT is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structures of two closely related but antigenically distinct HLA-A2/melanocyte-melanoma tumor-antigen peptide complexes., Sliz P, Michielin O, Cerottini JC, Luescher I, Romero P, Karplus M, Wiley DC, J Immunol. 2001 Sep 15;167(6):3276-84. PMID:11544315

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