1jk8: Difference between revisions

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[[Image:1jk8.jpg|left|200px]]
{{Seed}}
[[Image:1jk8.png|left|200px]]


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{{STRUCTURE_1jk8|  PDB=1jk8  |  SCENE=  }}  
{{STRUCTURE_1jk8|  PDB=1jk8  |  SCENE=  }}  


'''Crystal structure of a human insulin peptide-HLA-DQ8 complex'''
===Crystal structure of a human insulin peptide-HLA-DQ8 complex===




==Overview==
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The class II major histocompatibility complex (MHC) glycoproteins HLA-DQ8 and HLA-DQ2 in humans and I-A(g7) in nonobese diabetic (NOD) mice are the major risk factors for increased susceptibility to type 1 diabetes. Using X-ray crystallography, we have determined the three-dimensional structure of DQ8 complexed with an immunodominant peptide from insulin. The similarity of the DQ8, DQ2 and I-A(g7) peptide-binding pockets suggests that diabetes is caused by the same antigen-presentation event(s) in humans and NOD mice. Correlating type 1 diabetes epidemiology and MHC sequences with the DQ8 structure suggests that other structural features of the P9 pocket in addition to position 57 contribute to susceptibility to type 1 diabetes.
The line below this paragraph, {{ABSTRACT_PUBMED_11376336}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_11376336}}


==About this Structure==
==About this Structure==
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[[Category: Insulin b peptide]]
[[Category: Insulin b peptide]]
[[Category: Type 1 diabetes]]
[[Category: Type 1 diabetes]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:19:24 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:22:19 2008''

Revision as of 17:22, 1 July 2008

File:1jk8.png

Template:STRUCTURE 1jk8

Crystal structure of a human insulin peptide-HLA-DQ8 complex

Template:ABSTRACT PUBMED 11376336

About this Structure

1JK8 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes., Lee KH, Wucherpfennig KW, Wiley DC, Nat Immunol. 2001 Jun;2(6):501-7. PMID:11376336

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