1jmt: Difference between revisions

Line 1:

[[Image:1jmt.~~jpg~~|left|200px]]

[[Image:1jmt.png|left|200px]]

<!--

Line 9:

Line 10:

~~'''~~X-ray Structure of a Core U2AF65/U2AF35 Heterodimer~~'''~~

===X-ray Structure of a Core U2AF65/U2AF35 Heterodimer===

~~==Overview==~~

<!--

~~U2 auxiliary factor (U2AF) is an essential splicing factor that recognizes the 3' splice site and recruits~~ the ~~U2 snRNP~~ to the ~~branch point. The X-ray structure of the human core U2AF heterodimer, consisting of the U2AF35 central domain and a proline-rich region of U2AF65, has been determined~~ at 2.~~2 A resolution~~. ~~The structure reveals a novel protein-protein recognition strategy, in which an atypical RNA recognition motif (RRM~~) ~~of U2AF35 and the U2AF65 polyproline segment interact via reciprocal "tongue-in-groove" tryptophan residues. Complementary biochemical experiments demonstrate that the core U2AF heterodimer binds RNA~~, ~~and that~~ the ~~interacting tryptophan side chains are essential for U2AF dimerization~~. ~~Atypical RRMs in other splicing factors may serve as protein~~-~~protein interaction motifs elsewhere during spliceosome assembly.~~

The line below this paragraph, {{ABSTRACT_PUBMED_11551507}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 11551507 is the PubMed ID number.

-->

==About this Structure==

Line 31:

Line 35:

[[Category: Rna splicing]]

[[Category: Rrm]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May~~ ~~2 21~~:25:41 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:28:57 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:1jmt.jpg|left|200px]]
+{{Seed}}
+[[Image:1jmt.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1jmt|  PDB=1jmt  |  SCENE=  }}
-'''X-ray Structure of a Core U2AF65/U2AF35 Heterodimer'''
+===X-ray Structure of a Core U2AF65/U2AF35 Heterodimer===
-==Overview==
+<!--
-U2 auxiliary factor (U2AF) is an essential splicing factor that recognizes the 3' splice site and recruits the U2 snRNP to the branch point. The X-ray structure of the human core U2AF heterodimer, consisting of the U2AF35 central domain and a proline-rich region of U2AF65, has been determined at 2.2 A resolution. The structure reveals a novel protein-protein recognition strategy, in which an atypical RNA recognition motif (RRM) of U2AF35 and the U2AF65 polyproline segment interact via reciprocal "tongue-in-groove" tryptophan residues. Complementary biochemical experiments demonstrate that the core U2AF heterodimer binds RNA, and that the interacting tryptophan side chains are essential for U2AF dimerization. Atypical RRMs in other splicing factors may serve as protein-protein interaction motifs elsewhere during spliceosome assembly.
+The line below this paragraph, {{ABSTRACT_PUBMED_11551507}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 11551507 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_11551507}}
 ==About this Structure==
@@ Line 31: / Line 35: @@
 [[Category: Rna splicing]]
 [[Category: Rrm]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 21:25:41 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 20:28:57 2008''