1jmx: Difference between revisions

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[[Image:1jmx.~~jpg~~|left|200px]]

[[Image:1jmx.png|left|200px]]

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~~'''~~crystal structure of a quinohemoprotein amine dehydrogenase from pseudomonas putida~~'''~~

===crystal structure of a quinohemoprotein amine dehydrogenase from pseudomonas putida===

~~==Overview==~~

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The crystal structure of a quinohemoprotein amine dehydrogenase from Pseudomonas putida has been determined at 1.9-A resolution. The enzyme comprises three non-identical subunits: a four-domain alpha-subunit that harbors a di-heme cytochrome c, a seven-bladed beta-propeller beta-subunit that provides part of the active site, ~~and a small gamma-subunit that contains a novel cross-linked, proteinous quinone cofactor, cysteine tryptophylquinone. More surprisingly~~, the ~~catalytic gamma-subunit contains three additional chemical cross-links that encage~~ the cysteine tryptophylquinone cofactor, involving a cysteine side chain bridged to either an Asp or Glu residue all in a hitherto unknown thioether bonding with a methylene carbon atom of acidic amino acid side chains. ~~Thus~~, the ~~structure of the 79~~-~~residue gamma~~-~~subunit is quite unusual, containing four internal cross-links in such a short polypeptide chain that would otherwise be difficult to fold into a globular structure.~~

The line below this paragraph, {{ABSTRACT_PUBMED_11704672}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 11704672 is the PubMed ID number.

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==About this Structure==

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[[Category: Satoh, A.]]

[[Category: Amine dehydrogenase]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May~~ ~~2 21~~:25:57 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:29:17 2008''

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-[[Image:1jmx.jpg|left|200px]]
+{{Seed}}
+[[Image:1jmx.png|left|200px]]
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 {{STRUCTURE_1jmx|  PDB=1jmx  |  SCENE=  }}
-'''crystal structure of a quinohemoprotein amine dehydrogenase from pseudomonas putida'''
+===crystal structure of a quinohemoprotein amine dehydrogenase from pseudomonas putida===
-==Overview==
+<!--
-The crystal structure of a quinohemoprotein amine dehydrogenase from Pseudomonas putida has been determined at 1.9-A resolution. The enzyme comprises three non-identical subunits: a four-domain alpha-subunit that harbors a di-heme cytochrome c, a seven-bladed beta-propeller beta-subunit that provides part of the active site, and a small gamma-subunit that contains a novel cross-linked, proteinous quinone cofactor, cysteine tryptophylquinone. More surprisingly, the catalytic gamma-subunit contains three additional chemical cross-links that encage the cysteine tryptophylquinone cofactor, involving a cysteine side chain bridged to either an Asp or Glu residue all in a hitherto unknown thioether bonding with a methylene carbon atom of acidic amino acid side chains. Thus, the structure of the 79-residue gamma-subunit is quite unusual, containing four internal cross-links in such a short polypeptide chain that would otherwise be difficult to fold into a globular structure.
+The line below this paragraph, {{ABSTRACT_PUBMED_11704672}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 11704672 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_11704672}}
 ==About this Structure==
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 [[Category: Satoh, A.]]
 [[Category: Amine dehydrogenase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 21:25:57 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 20:29:17 2008''