1joy: Difference between revisions

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[[Image:1joy.jpg|left|200px]]
{{Seed}}
[[Image:1joy.png|left|200px]]


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{{STRUCTURE_1joy|  PDB=1joy  |  SCENE=  }}  
{{STRUCTURE_1joy|  PDB=1joy  |  SCENE=  }}  


'''SOLUTION STRUCTURE OF THE HOMODIMERIC DOMAIN OF ENVZ FROM ESCHERICHIA COLI BY MULTI-DIMENSIONAL NMR.'''
===SOLUTION STRUCTURE OF THE HOMODIMERIC DOMAIN OF ENVZ FROM ESCHERICHIA COLI BY MULTI-DIMENSIONAL NMR.===




==Overview==
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Escherichia coli osmosensor EnvZ is a protein histidine kinase that plays a central role in osmoregulation, a cellular adaptation process involving the His-Asp phosphorelay signal transduction system. Dimerization of the transmembrane protein is essential for its autophosphorylation and phosphorelay signal transduction functions. Here we present the NMR-derived structure of the homodimeric core domain (residues 223-289) of EnvZ that includes His 243, the site of autophosphorylation and phosphate transfer reactions. The structure comprises a four-helix bundle formed by two identical helix-turn-helix subunits, revealing the molecular assembly of two active sites within the dimeric kinase.
The line below this paragraph, {{ABSTRACT_PUBMED_10426948}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 10426948 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10426948}}


==About this Structure==
==About this Structure==
1JOY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JOY OCA].  
1JOY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JOY OCA].  


==Reference==
==Reference==
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[[Category: Phosphorylation]]
[[Category: Phosphorylation]]
[[Category: Sensory transduction]]
[[Category: Sensory transduction]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:31:56 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:34:43 2008''
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