1jro: Difference between revisions

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[[Image:1jro.gif|left|200px]]
{{Seed}}
[[Image:1jro.png|left|200px]]


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{{STRUCTURE_1jro|  PDB=1jro  |  SCENE=  }}  
{{STRUCTURE_1jro|  PDB=1jro  |  SCENE=  }}  


'''Crystal Structure of Xanthine Dehydrogenase from Rhodobacter capsulatus'''
===Crystal Structure of Xanthine Dehydrogenase from Rhodobacter capsulatus===




==Overview==
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Xanthine dehydrogenase (XDH), a complex molybdo/iron-sulfur/flavoprotein, catalyzes the oxidation of hypoxanthine to xanthine followed by oxidation of xanthine to uric acid with concomitant reduction of NAD+. The 2.7 A resolution structure of Rhodobacter capsulatus XDH reveals that the bacterial and bovine XDH have highly similar folds despite differences in subunit composition. The NAD+ binding pocket of the bacterial XDH resembles that of the dehydrogenase form of the bovine enzyme rather than that of the oxidase form, which reduces O(2) instead of NAD+. The drug allopurinol is used to treat XDH-catalyzed uric acid build-up occurring in gout or during cancer chemotherapy. As a hypoxanthine analog, it is oxidized to alloxanthine, which cannot be further oxidized but acts as a tight binding inhibitor of XDH. The 3.0 A resolution structure of the XDH-alloxanthine complex shows direct coordination of alloxanthine to the molybdenum via a nitrogen atom. These results provide a starting point for the rational design of new XDH inhibitors.
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{{ABSTRACT_PUBMED_11796116}}


==About this Structure==
==About this Structure==
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[[Category: Xdh]]
[[Category: Xdh]]
[[Category: Xo]]
[[Category: Xo]]
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Revision as of 17:42, 1 July 2008

File:1jro.png

Template:STRUCTURE 1jro

Crystal Structure of Xanthine Dehydrogenase from Rhodobacter capsulatus

Template:ABSTRACT PUBMED 11796116

About this Structure

1JRO is a Protein complex structure of sequences from Rhodobacter capsulatus. Full crystallographic information is available from OCA.

Reference

Crystal structures of the active and alloxanthine-inhibited forms of xanthine dehydrogenase from Rhodobacter capsulatus., Truglio JJ, Theis K, Leimkuhler S, Rappa R, Rajagopalan KV, Kisker C, Structure. 2002 Jan;10(1):115-25. PMID:11796116

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