1jsa: Difference between revisions

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[[Image:1jsa.gif|left|200px]]
{{Seed}}
[[Image:1jsa.png|left|200px]]


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{{STRUCTURE_1jsa|  PDB=1jsa  |  SCENE=  }}  
{{STRUCTURE_1jsa|  PDB=1jsa  |  SCENE=  }}  


'''MYRISTOYLATED RECOVERIN WITH TWO CALCIUMS BOUND, NMR, 24 STRUCTURES'''
===MYRISTOYLATED RECOVERIN WITH TWO CALCIUMS BOUND, NMR, 24 STRUCTURES===




==Overview==
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Many eukaryotic cellular and viral proteins have a covalently attached myristoyl group at the amino terminus. One such protein is recoverin, a calcium sensor in retinal rod cells, which controls the lifetime of photoexcited rhodopsin by inhibiting rhodopsin kinase. Recoverin has a relative molecular mass of 23,000 (M[r] 23K), and contains an amino-terminal myristoyl group (or related acyl group) and four EF hands. The binding of two Ca2+ ions to recoverin leads to its translocation from the cytosol to the disc membrane. In the Ca2+-free state, the myristoyl group is sequestered in a deep hydrophobic box, where it is clamped by multiple residues contributed by three of the EF hands. We have used nuclear magnetic resonance to show that Ca2+ induces the unclamping and extrusion of the myristoyl group, enabling it to interact with a lipid bilayer membrane. The transition is also accompanied by a 45-degree rotation of the amino-terminal domain relative to the carboxy-terminal domain, and many hydrophobic residues are exposed. The conservation of the myristoyl binding site and two swivels in recoverin homologues from yeast to humans indicates that calcium-myristoyl switches are ancient devices for controlling calcium-sensitive processes.
The line below this paragraph, {{ABSTRACT_PUBMED_9296500}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 9296500 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9296500}}


==About this Structure==
==About this Structure==
1JSA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JSA OCA].  
1JSA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JSA OCA].  


==Reference==
==Reference==
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[[Category: Calcium binding protein]]
[[Category: Calcium binding protein]]
[[Category: Calcium-myristoyl switch]]
[[Category: Calcium-myristoyl switch]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:49:53 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:43:41 2008''

Revision as of 17:43, 1 July 2008

File:1jsa.png

Template:STRUCTURE 1jsa

MYRISTOYLATED RECOVERIN WITH TWO CALCIUMS BOUND, NMR, 24 STRUCTURES

Template:ABSTRACT PUBMED 9296500

About this Structure

1JSA is a Single protein structure of sequence from Bos taurus. Full experimental information is available from OCA.

Reference

Molecular mechanics of calcium-myristoyl switches., Ames JB, Ishima R, Tanaka T, Gordon JI, Stryer L, Ikura M, Nature. 1997 Sep 11;389(6647):198-202. PMID:9296500

Page seeded by OCA on Tue Jul 1 20:43:41 2008

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