1k78: Difference between revisions

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[[Image:1k78.gif|left|200px]]
{{Seed}}
[[Image:1k78.png|left|200px]]


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{{STRUCTURE_1k78|  PDB=1k78  |  SCENE=  }}  
{{STRUCTURE_1k78|  PDB=1k78  |  SCENE=  }}  


'''Pax5(1-149)+Ets-1(331-440)+DNA'''
===Pax5(1-149)+Ets-1(331-440)+DNA===




==Overview==
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Pax5 regulates the B cell-specific expression of the mb-1 gene together with members of the Ets family of transcriptional activators. The Ets proteins on their own bind poorly to the Pax5/Ets binding site, but can be recruited to the site by cooperative interactions with Pax5. The structure of the ETS domain of Ets-1 and the paired domain of Pax5 bound to DNA reveals the molecular details of the selective recruitment of different Ets proteins by Pax5. Comparison with structures of Ets-1 alone bound to both high- and low-affinity DNA sites reveals that Pax5 alters the Ets-1 contacts with DNA. The ability of one protein to alter the DNA sequence-specific contacts of another provides a general mechanism for combinatorial regulation of transcription.
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{{ABSTRACT_PUBMED_11779502}}


==Disease==
==Disease==
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[[Category: Paired domain]]
[[Category: Paired domain]]
[[Category: Transcription factor]]
[[Category: Transcription factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 09:53:41 2008''

Revision as of 06:53, 2 July 2008

File:1k78.png

Template:STRUCTURE 1k78

Pax5(1-149)+Ets-1(331-440)+DNA

Template:ABSTRACT PUBMED 11779502

Disease

Known disease associated with this structure: Lymphoplasmacytoid lymphoma OMIM:[167414]

About this Structure

1K78 is a Protein complex structure of sequences from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural studies of Ets-1/Pax5 complex formation on DNA., Garvie CW, Hagman J, Wolberger C, Mol Cell. 2001 Dec;8(6):1267-76. PMID:11779502

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