1k8w: Difference between revisions

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[[Image:1k8w.gif|left|200px]]
{{Seed}}
[[Image:1k8w.png|left|200px]]


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{{STRUCTURE_1k8w|  PDB=1k8w  |  SCENE=  }}  
{{STRUCTURE_1k8w|  PDB=1k8w  |  SCENE=  }}  


'''Crystal structure of the E. coli pseudouridine synthase TruB bound to a T stem-loop RNA'''
===Crystal structure of the E. coli pseudouridine synthase TruB bound to a T stem-loop RNA===




==Overview==
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Pseudouridine (Psi) synthases catalyze the isomerization of specific uridines in cellular RNAs to pseudouridines and may function as RNA chaperones. TruB is responsible for the Psi residue present in the T loops of virtually all tRNAs. The close homolog Cbf5/dyskerin is the catalytic subunit of box H/ACA snoRNPs. These carry out the pseudouridylation of eukaryotic rRNA and snRNAs. The 1.85 A resolution structure of TruB bound to RNA reveals that this enzyme recognizes the preformed three-dimensional structure of the T loop, primarily through shape complementarity. It accesses its substrate uridyl residue by flipping out the nucleotide and disrupts the tertiary structure of tRNA. Structural comparisons with TruB demonstrate that all Psi synthases are descended from a common molecular ancestor.
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{{ABSTRACT_PUBMED_11779468}}


==About this Structure==
==About this Structure==
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[[Category: T stem-loop]]
[[Category: T stem-loop]]
[[Category: Trna]]
[[Category: Trna]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:26:59 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 09:57:57 2008''

Revision as of 06:57, 2 July 2008

File:1k8w.png

Template:STRUCTURE 1k8w

Crystal structure of the E. coli pseudouridine synthase TruB bound to a T stem-loop RNA

Template:ABSTRACT PUBMED 11779468

About this Structure

1K8W is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Cocrystal structure of a tRNA Psi55 pseudouridine synthase: nucleotide flipping by an RNA-modifying enzyme., Hoang C, Ferre-D'Amare AR, Cell. 2001 Dec 28;107(7):929-39. PMID:11779468

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