1kcg: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
Line 1: Line 1:
[[Image:1kcg.gif|left|200px]]
{{Seed}}
[[Image:1kcg.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1kcg|  PDB=1kcg  |  SCENE=  }}  
{{STRUCTURE_1kcg|  PDB=1kcg  |  SCENE=  }}  


'''NKG2D in complex with ULBP3'''
===NKG2D in complex with ULBP3===




==Overview==
<!--
NKG2D is known to trigger the natural killer (NK) cell lysis of various tumor and virally infected cells. In the NKG2D/ULBP3 complex, the structure of ULBP3 resembles the alpha1 and alpha2 domains of classical MHC molecules without a bound peptide. The lack of alpha3 and beta2m domains is compensated by replacing two hydrophobic patches at the underside of the class I MHC-like beta sheet floor with a group of hydrophilic and charged residues in ULBP3. NKG2D binds diagonally across the ULBP3 alpha helices, creating a complementary interface, an asymmetrical subunit orientation, and local conformational adjustments in the receptor. The interface is stabilized primarily by hydrogen bonds and hydrophobic interactions. Unlike the KIR receptors that recognize a conserved HLA region by a lock-and-key mechanism, NKG2D recognizes diverse ligands by an induced-fit mechanism.
The line below this paragraph, {{ABSTRACT_PUBMED_11754823}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 11754823 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_11754823}}


==About this Structure==
==About this Structure==
Line 27: Line 31:
[[Category: Mhc class i-like molecule]]
[[Category: Mhc class i-like molecule]]
[[Category: Protein-protein complex]]
[[Category: Protein-protein complex]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:34:23 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:07:41 2008''

Revision as of 07:07, 2 July 2008

File:1kcg.png

Template:STRUCTURE 1kcg

NKG2D in complex with ULBP3

Template:ABSTRACT PUBMED 11754823

About this Structure

1KCG is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Conformational plasticity revealed by the cocrystal structure of NKG2D and its class I MHC-like ligand ULBP3., Radaev S, Rostro B, Brooks AG, Colonna M, Sun PD, Immunity. 2001 Dec;15(6):1039-49. PMID:11754823

Page seeded by OCA on Wed Jul 2 10:07:41 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=1kcg&oldid=620174"