1kfp: Difference between revisions

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[[Image:1kfp.gif|left|200px]]
{{Seed}}
[[Image:1kfp.png|left|200px]]


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{{STRUCTURE_1kfp|  PDB=1kfp  |  SCENE=  }}  
{{STRUCTURE_1kfp|  PDB=1kfp  |  SCENE=  }}  


'''Solution structure of the antimicrobial 18-residue gomesin'''
===Solution structure of the antimicrobial 18-residue gomesin===




==Overview==
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Gomesin is the first peptide isolated from spider exhibiting antimicrobial activities. This highly cationic peptide is composed of 18 amino-acid residues including four cysteines forming two disulfide linkages. The solution structure of gomesin has been determined using proton two-dimensional NMR (2D-NMR) and restrained molecular dynamics calculations. The global fold of gomesin consists in a well-resolved two-stranded antiparallel betasheet connected by a noncanonical betaturn. A comparison between the structures of gomesin and protegrin-1 from porcine and androctonin from scorpion outlines several common features in the distribution of hydrophobic and hydrophilic residues. The N- and C-termini, the betaturn and one face of the betasheet are hydrophilic, but the hydrophobicity of the other face depends on the peptide. The similarities suggest that the molecules interact with membranes in an analogous manner. The importance of the intramolecular disulfide bridges in the biological activity of gomesin is being investigated.
The line below this paragraph, {{ABSTRACT_PUBMED_11856345}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_11856345}}


==About this Structure==
==About this Structure==
1KFP is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KFP OCA].  
1KFP is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KFP OCA].  


==Reference==
==Reference==
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[[Category: Disulfide bridge]]
[[Category: Disulfide bridge]]
[[Category: Hairpin-like]]
[[Category: Hairpin-like]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:16:32 2008''

Revision as of 07:16, 2 July 2008

File:1kfp.png

Template:STRUCTURE 1kfp

Solution structure of the antimicrobial 18-residue gomesin

Template:ABSTRACT PUBMED 11856345

About this Structure

1KFP is a Single protein structure. Full experimental information is available from OCA.

Reference

The solution structure of gomesin, an antimicrobial cysteine-rich peptide from the spider., Mandard N, Bulet P, Caille A, Daffre S, Vovelle F, Eur J Biochem. 2002 Feb;269(4):1190-8. PMID:11856345

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