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| {{STRUCTURE_1kix| PDB=1kix | SCENE= }} | | {{STRUCTURE_1kix| PDB=1kix | SCENE= }} |
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| '''Dimeric Structure of the O. nova Telomere End Binding Protein Alpha Subunit with Bound ssDNA'''
| | ===Dimeric Structure of the O. nova Telomere End Binding Protein Alpha Subunit with Bound ssDNA=== |
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| ==Overview==
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| Telomeres are the specialized protein--DNA complexes that cap and protect the ends of linear eukaryotic chromosomes. The extreme 3' end of the telomeric DNA in Oxytricha nova is bound by a two-subunit sequence-specific and 3' end-specific protein called the telomere end-binding protein (OnTEBP). Here we describe the crystal structure of the alpha-subunit of OnTEBP in complex with T4G4 single-stranded telomeric DNA. This structure shows an (alpha--ssDNA)2 homodimer with a large approximately 7,000 A2 protein--protein interface in which the domains of alpha are rearranged extensively from their positions in the structure of an alpha--beta--ssDNA ternary complex. The (alpha--ssDNA)2 complex can bind two telomeres on opposite sides of the dimer and, thus, acts as a protein mediator of telomere--telomere associations. The structures of the (alpha--ssDNA)2 dimer presented here and the previously described alpha--beta--ssDNA complex demonstrate that OnTEBP forms multiple telomeric complexes that potentially mediate the assembly and disassembly of higher order telomeric structures.
| | The line below this paragraph, {{ABSTRACT_PUBMED_11836536}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 11836536 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_11836536}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Ssdna]] | | [[Category: Ssdna]] |
| [[Category: Telomere binding protein]] | | [[Category: Telomere binding protein]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:48:08 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:24:43 2008'' |
