1kn2: Difference between revisions

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[[Image:1kn2.gif|left|200px]]
{{Seed}}
[[Image:1kn2.png|left|200px]]


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{{STRUCTURE_1kn2|  PDB=1kn2  |  SCENE=  }}  
{{STRUCTURE_1kn2|  PDB=1kn2  |  SCENE=  }}  


'''CATALYTIC ANTIBODY D2.3 COMPLEX'''
===CATALYTIC ANTIBODY D2.3 COMPLEX===




==Overview==
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The crystal structures of catalytic antibody D2.3 Fab with the two enantiomers, 7D and 7L, which represent transition state analogues for the hydrolysis of the corresponding esters, 6D and 6L, were determined to better understand remarkable reactivity differences: the L-ester displayed significantly tighter binding (K(M)) and increased catalytic activity (k(cat)) with D2.3, even though the chiral center is 7 bonds distant from the reaction center. Surprisingly, the electron densities of the liganded phosphonates, 7D and 7L, within the D2.3 binding/reaction site were essentially identical, highlighting the subtle influences of protein interactions on chemical behavior.
The line below this paragraph, {{ABSTRACT_PUBMED_11878955}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_11878955}}


==About this Structure==
==About this Structure==
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[[Category: Immune system]]
[[Category: Immune system]]
[[Category: Transition state analog]]
[[Category: Transition state analog]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:56:04 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:34:49 2008''
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