1kn4: Difference between revisions

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[[Image:1kn4.gif|left|200px]]
{{Seed}}
[[Image:1kn4.png|left|200px]]


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{{STRUCTURE_1kn4|  PDB=1kn4  |  SCENE=  }}  
{{STRUCTURE_1kn4|  PDB=1kn4  |  SCENE=  }}  


'''CATALYTIC ANTIBODY D2.3 COMPLEX'''
===CATALYTIC ANTIBODY D2.3 COMPLEX===




==Overview==
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The crystal structures of catalytic antibody D2.3 Fab with the two enantiomers, 7D and 7L, which represent transition state analogues for the hydrolysis of the corresponding esters, 6D and 6L, were determined to better understand remarkable reactivity differences: the L-ester displayed significantly tighter binding (K(M)) and increased catalytic activity (k(cat)) with D2.3, even though the chiral center is 7 bonds distant from the reaction center. Surprisingly, the electron densities of the liganded phosphonates, 7D and 7L, within the D2.3 binding/reaction site were essentially identical, highlighting the subtle influences of protein interactions on chemical behavior.
The line below this paragraph, {{ABSTRACT_PUBMED_11878955}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_11878955}}


==About this Structure==
==About this Structure==
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[[Category: Immune system]]
[[Category: Immune system]]
[[Category: Transition state analog]]
[[Category: Transition state analog]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:56:16 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:35:01 2008''

Revision as of 07:35, 2 July 2008

File:1kn4.png

Template:STRUCTURE 1kn4

CATALYTIC ANTIBODY D2.3 COMPLEX

Template:ABSTRACT PUBMED 11878955

About this Structure

1KN4 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Remarkable remote chiral recognition in a reaction mediated by a catalytic antibody., D'Souza LJ, Gigant B, Knossow M, Green BS, J Am Chem Soc. 2002 Mar 13;124(10):2114-5. PMID:11878955

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