1kpy: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
Line 1: Line 1:
[[Image:1kpy.gif|left|200px]]
{{Seed}}
[[Image:1kpy.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1kpy|  PDB=1kpy  |  SCENE=  }}  
{{STRUCTURE_1kpy|  PDB=1kpy  |  SCENE=  }}  


'''PEMV-1 P1-P2 Frameshifting Pseudoknot, 15 Lowest Energy Structures'''
===PEMV-1 P1-P2 Frameshifting Pseudoknot, 15 Lowest Energy Structures===




==Overview==
<!--  
A hairpin-type messenger RNA pseudoknot from pea enation mosaic virus RNA1 (PEMV-1) regulates the efficiency of programmed -1 ribosomal frameshifting. The solution structure and 15N relaxation rates reveal that the PEMV-1 pseudoknot is a compact-folded structure composed almost entirely of RNA triple helix. A three nucleotide reverse turn in loop 1 positions a protonated cytidine, C(10), in the correct orientation to form an A((n-1)).C(+).G-C(n) major groove base quadruple, like that found in the beet western yellows virus pseudoknot and the hepatitis delta virus ribozyme, despite distinct structural contexts. A novel loop 2-loop 1 A.U Hoogsteen base-pair stacks on the C(10)(+).G(28) base-pair of the A(12).C(10)(+).G(28)-C(13) quadruple and forms a wedge between the pseudoknot stems stabilizing a bent and over-rotated global conformation. Substitution of key nucleotides that stabilize the unique conformation of the PEMV-1 pseudoknot greatly reduces ribosomal frameshifting efficacy.
The line below this paragraph, {{ABSTRACT_PUBMED_12225754}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 12225754 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_12225754}}


==About this Structure==
==About this Structure==
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KPY OCA].  
Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KPY OCA].  


==Reference==
==Reference==
Line 29: Line 33:
[[Category: Ribonucleic acid]]
[[Category: Ribonucleic acid]]
[[Category: Triple helix]]
[[Category: Triple helix]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:01:43 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:44:25 2008''

Revision as of 07:44, 2 July 2008

File:1kpy.png

Template:STRUCTURE 1kpy

PEMV-1 P1-P2 Frameshifting Pseudoknot, 15 Lowest Energy Structures

Template:ABSTRACT PUBMED 12225754

About this Structure

Full experimental information is available from OCA.

Reference

Solution structure of a luteoviral P1-P2 frameshifting mRNA pseudoknot., Nixon PL, Rangan A, Kim YG, Rich A, Hoffman DW, Hennig M, Giedroc DP, J Mol Biol. 2002 Sep 20;322(3):621-33. PMID:12225754

Page seeded by OCA on Wed Jul 2 10:44:25 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=1kpy&oldid=621954"