1ksh: Difference between revisions

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[[Image:1ksh.gif|left|200px]]
{{Seed}}
[[Image:1ksh.png|left|200px]]


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{{STRUCTURE_1ksh|  PDB=1ksh  |  SCENE=  }}  
{{STRUCTURE_1ksh|  PDB=1ksh  |  SCENE=  }}  


'''Complex of Arl2 and PDE delta, Crystal Form 2 (native)'''
===Complex of Arl2 and PDE delta, Crystal Form 2 (native)===




==Overview==
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Arf-like (Arl) proteins are close relatives of the Arf regulators of vesicular transport, but their function is unknown. Here, we present the crystal structure of full-length Arl2-GTP in complex with its effector PDE delta solved in two crystal forms (Protein Data Bank codes 1KSG, 1KSH and 1KSJ). Arl2 shows a dramatic conformational change from the GDP-bound form, which suggests that it is reversibly membrane associated. PDE delta is structurally closely related to RhoGDI and contains a deep empty hydrophobic pocket. Further experiments show that H-Ras, Rheb, Rho6 and G alpha(i1) interact with PDE delta and that, at least for H-Ras, the intact C-terminus is required. We suggest PDE delta to be a specific soluble transport factor for certain prenylated proteins and Arl2-GTP a regulator of PDE delta-mediated transport.
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{{ABSTRACT_PUBMED_11980706}}


==About this Structure==
==About this Structure==
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[[Category: Small gtp-binding protein]]
[[Category: Small gtp-binding protein]]
[[Category: Small gtpase]]
[[Category: Small gtpase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:06:55 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:53:53 2008''

Revision as of 07:53, 2 July 2008

File:1ksh.png

Template:STRUCTURE 1ksh

Complex of Arl2 and PDE delta, Crystal Form 2 (native)

Template:ABSTRACT PUBMED 11980706

About this Structure

1KSH is a Protein complex structure of sequences from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.

Reference

The complex of Arl2-GTP and PDE delta: from structure to function., Hanzal-Bayer M, Renault L, Roversi P, Wittinghofer A, Hillig RC, EMBO J. 2002 May 1;21(9):2095-106. PMID:11980706

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