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| [[Image:1kuj.gif|left|200px]] | | {{Seed}} |
| | [[Image:1kuj.png|left|200px]] |
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| {{STRUCTURE_1kuj| PDB=1kuj | SCENE= }} | | {{STRUCTURE_1kuj| PDB=1kuj | SCENE= }} |
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| '''Crystal structure of Jacalin complexed with 1-O-methyl-alpha-D-mannose'''
| | ===Crystal structure of Jacalin complexed with 1-O-methyl-alpha-D-mannose=== |
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| ==Overview==
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| Evidence is presented that the specificity of jacalin, the seed lectin from jack fruit (Artocarpus integrifolia), is not directed exclusively against the T-antigen disaccharide Galbeta1,3GalNAc, lactose and galactose, but also against mannose and oligomannosides. Biochemical analyses based on surface-plasmon-resonance measurements, combined with the X-ray-crystallographic determination of the structure of a jacalin-alpha-methyl-mannose complex at 2 A resolution, demonstrated clearly that jacalin is fully capable of binding mannose. Besides mannose, jacalin also interacts readily with glucose, N-acetylneuraminic acid and N-acetylmuramic acid. Structural analyses demonstrated that the relatively large size of the carbohydrate-binding site enables jacalin to accommodate monosaccharides with different hydroxyl conformations and provided unambiguous evidence that the beta-prism structure of jacalin is a sufficiently flexible structural scaffold to confer different carbohydrate-binding specificities to a single lectin.
| | The line below this paragraph, {{ABSTRACT_PUBMED_11988090}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 11988090 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_11988090}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Carbohydrate binding]] | | [[Category: Carbohydrate binding]] |
| [[Category: Lectin]] | | [[Category: Lectin]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:11:09 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 11:01:49 2008'' |
