1ky2: Difference between revisions

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[[Image:1ky2.jpg|left|200px]]
{{Seed}}
[[Image:1ky2.png|left|200px]]


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{{STRUCTURE_1ky2|  PDB=1ky2  |  SCENE=  }}  
{{STRUCTURE_1ky2|  PDB=1ky2  |  SCENE=  }}  


'''GPPNHP-BOUND YPT7P AT 1.6 A RESOLUTION'''
===GPPNHP-BOUND YPT7P AT 1.6 A RESOLUTION===




==Overview==
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The GTPase Ypt7p from S. cerevisiae is involved in late endosome-to-vacuole transport and homotypic vacuole fusion. We present crystal structures of the GDP- and GppNHp-bound conformation of Ypt7p solved at 1.35 and 1.6 A resolution, respectively. Despite the similarity of the overall structure to other Ypt/Rab proteins, Ypt7p displays small but significant differences. The Ypt7p-specific residues Tyr33 and Tyr37 cause a difference in the main chain trace of the RabSF2 region and form a characteristic surface epitope. Ypt7p*GppNHp does not display the helix alpha2, characteristic of the Ras-superfamily, but instead possess an extended loop L4/L5. Due to insertions in loops L3 and L7, the neighboring RabSF1 and RabSF4 regions are different in their conformations to those of other Ypt/Rab proteins.
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{{ABSTRACT_PUBMED_11937061}}


==About this Structure==
==About this Structure==
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[[Category: Vesicular traffic]]
[[Category: Vesicular traffic]]
[[Category: Ypt/rab protein]]
[[Category: Ypt/rab protein]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:18:48 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 11:16:18 2008''

Revision as of 08:16, 2 July 2008

File:1ky2.png

Template:STRUCTURE 1ky2

GPPNHP-BOUND YPT7P AT 1.6 A RESOLUTION

Template:ABSTRACT PUBMED 11937061

About this Structure

1KY2 is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Rab-subfamily-specific regions of Ypt7p are structurally different from other RabGTPases., Constantinescu AT, Rak A, Alexandrov K, Esters H, Goody RS, Scheidig AJ, Structure. 2002 Apr;10(4):569-79. PMID:11937061

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