1kzz: Difference between revisions

Line 1:

[[Image:1kzz.~~jpg~~|left|200px]]

[[Image:1kzz.png|left|200px]]

<!--

Line 9:

Line 10:

~~'''~~DOWNSTREAM REGULATOR TANK BINDS TO THE CD40 RECOGNITION SITE ON TRAF3~~'''~~

===DOWNSTREAM REGULATOR TANK BINDS TO THE CD40 RECOGNITION SITE ON TRAF3===

~~==Overview==~~

<!--

~~TRAFs (tumor necrosis factor receptor [TNFR]~~-~~associated factors) bind to the cytoplasmic portion of liganded TNFRs and stimulate activation of NF~~-~~kappaB or JNK pathways. A modulator of TRAF signaling~~, ~~TANK~~, serves as either an enhancer or an inhibitor of TRAF-mediated signaling pathways. The crystal structure of a region of TANK bound to TRAF3 has been determined and compared to a similar CD40/TRAF3 complex. TANK and CD40 bind to the ~~same crevice~~ on ~~TRAF3~~. ~~The recognition motif PxQxT is presented in a boomerang-like structure in TANK that is markedly different from the hairpin loop that forms in CD40 upon binding to TRAF3~~. ~~Critical TANK contact residues were confirmed by mutagenesis to be required for binding to TRAF3 or TRAF2. Binding affinity~~, ~~measured by isothermal titration calorimetry and competition assays, demonstrated that TANK competes with CD40 for~~ the ~~TRAF binding site~~.

The line below this paragraph, {{ABSTRACT_PUBMED_12005438}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 12005438 is the PubMed ID number.

-->

==About this Structure==

Line 37:

Line 41:

[[Category: Tnf receptor]]

[[Category: Traf3]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May~~ 2 23:23:05 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 11:23:59 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:1kzz.jpg|left|200px]]
+{{Seed}}
+[[Image:1kzz.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1kzz|  PDB=1kzz  |  SCENE=  }}
-'''DOWNSTREAM REGULATOR TANK BINDS TO THE CD40 RECOGNITION SITE ON TRAF3'''
+===DOWNSTREAM REGULATOR TANK BINDS TO THE CD40 RECOGNITION SITE ON TRAF3===
-==Overview==
+<!--
-TRAFs (tumor necrosis factor receptor [TNFR]-associated factors) bind to the cytoplasmic portion of liganded TNFRs and stimulate activation of NF-kappaB or JNK pathways. A modulator of TRAF signaling, TANK, serves as either an enhancer or an inhibitor of TRAF-mediated signaling pathways. The crystal structure of a region of TANK bound to TRAF3 has been determined and compared to a similar CD40/TRAF3 complex. TANK and CD40 bind to the same crevice on TRAF3. The recognition motif PxQxT is presented in a boomerang-like structure in TANK that is markedly different from the hairpin loop that forms in CD40 upon binding to TRAF3. Critical TANK contact residues were confirmed by mutagenesis to be required for binding to TRAF3 or TRAF2. Binding affinity, measured by isothermal titration calorimetry and competition assays, demonstrated that TANK competes with CD40 for the TRAF binding site.
+The line below this paragraph, {{ABSTRACT_PUBMED_12005438}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 12005438 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_12005438}}
 ==About this Structure==
@@ Line 37: / Line 41: @@
 [[Category: Tnf receptor]]
 [[Category: Traf3]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 23:23:05 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul  2 11:23:59 2008''