1l2g: Difference between revisions

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[[Image:1l2g.jpg|left|200px]]
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[[Image:1l2g.png|left|200px]]


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{{STRUCTURE_1l2g|  PDB=1l2g  |  SCENE=  }}  
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'''Structure of a C-terminally truncated form of glycoprotein D from HSV-1'''
===Structure of a C-terminally truncated form of glycoprotein D from HSV-1===




==Overview==
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Herpes simplex virus (HSV) infection requires binding of the viral envelope glycoprotein D (gD) to cell surface receptors. We report the X-ray structures of a soluble, truncated ectodomain of gD both alone and in complex with the ectodomain of its cellular receptor HveA. Two bound anions suggest possible binding sites for another gD receptor, a 3-O-sulfonated heparan sulfate. Unexpectedly, the structures reveal a V-like immunoglobulin (Ig) fold at the core of gD that is closely related to cellular adhesion molecules and flanked by large N- and C-terminal extensions. The receptor binding segment of gD, an N-terminal hairpin, appears conformationally flexible, suggesting that a conformational change accompanying binding might be part of the viral entry mechanism.
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{{ABSTRACT_PUBMED_11511370}}


==About this Structure==
==About this Structure==
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[[Category: Ig fold]]
[[Category: Ig fold]]
[[Category: Viral envelope glycoprotein]]
[[Category: Viral envelope glycoprotein]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:27:47 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 11:32:55 2008''

Revision as of 08:32, 2 July 2008

File:1l2g.png

Template:STRUCTURE 1l2g

Structure of a C-terminally truncated form of glycoprotein D from HSV-1

Template:ABSTRACT PUBMED 11511370

About this Structure

1L2G is a Single protein structure of sequence from Human herpesvirus 1. Full crystallographic information is available from OCA.

Reference

Herpes simplex virus glycoprotein D bound to the human receptor HveA., Carfi A, Willis SH, Whitbeck JC, Krummenacher C, Cohen GH, Eisenberg RJ, Wiley DC, Mol Cell. 2001 Jul;8(1):169-79. PMID:11511370

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