1l2q: Difference between revisions

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[[Image:1l2q.jpg|left|200px]]
{{Seed}}
[[Image:1l2q.png|left|200px]]


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{{STRUCTURE_1l2q|  PDB=1l2q  |  SCENE=  }}  
{{STRUCTURE_1l2q|  PDB=1l2q  |  SCENE=  }}  


'''Crystal Structure of the Methanosarcina barkeri Monomethylamine Methyltransferase (MtmB)'''
===Crystal Structure of the Methanosarcina barkeri Monomethylamine Methyltransferase (MtmB)===




==Overview==
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Genes encoding methanogenic methylamine methyltransferases all contain an in-frame amber (UAG) codon that is read through during translation. We have identified the UAG-encoded residue in a 1.55 angstrom resolution structure of the Methanosarcina barkeri monomethylamine methyltransferase (MtmB). This structure reveals a homohexamer comprised of individual subunits with a TIM barrel fold. The electron density for the UAG-encoded residue is distinct from any of the 21 natural amino acids. Instead it appears consistent with a lysine in amide-linkage to (4R,5R)-4-substituted-pyrroline-5-carboxylate. We suggest that this amino acid be named l-pyrrolysine.
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{{ABSTRACT_PUBMED_12029132}}


==About this Structure==
==About this Structure==
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[[Category: Krzycki, J A.]]
[[Category: Krzycki, J A.]]
[[Category: Tim barrel]]
[[Category: Tim barrel]]
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