1l3a: Difference between revisions

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[[Image:1l3a.jpg|left|200px]]
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[[Image:1l3a.png|left|200px]]


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{{STRUCTURE_1l3a|  PDB=1l3a  |  SCENE=  }}  
{{STRUCTURE_1l3a|  PDB=1l3a  |  SCENE=  }}  


'''Structure of the plant transcriptional regulator PBF-2'''
===Structure of the plant transcriptional regulator PBF-2===




==Overview==
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The crystal structure of p24, the single-stranded DNA (ssDNA) binding subunit of the plant defense transcription factor PBF-2, has been determined to 2.3 A resolution. p24 is representative of a novel family of ubiquitous plant-specific proteins that we refer to as the Whirly family because of their quaternary structure. PBF-2 is composed of four p24 molecules that interact through a helix-loop-helix motif. This interaction produces a central pore, with beta-strands radiating outwards, resulting in a whirligig appearance to the quaternary structure. The noncrystallographic C(4) symmetry arrangement of p24 subunits is novel for ssDNA binding proteins and may explain the binding specificity of PBF-2. This structural arrangement also supports the role of PBF-2 in binding melted promoter regions to modulate gene expression.
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{{ABSTRACT_PUBMED_12080340}}


==About this Structure==
==About this Structure==
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[[Category: Transcriptionnal activator]]
[[Category: Transcriptionnal activator]]
[[Category: Whirly]]
[[Category: Whirly]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:29:31 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 11:36:25 2008''

Revision as of 08:36, 2 July 2008

File:1l3a.png

Template:STRUCTURE 1l3a

Structure of the plant transcriptional regulator PBF-2

Template:ABSTRACT PUBMED 12080340

About this Structure

1L3A is a Single protein structure of sequence from Solanum tuberosum. Full crystallographic information is available from OCA.

Reference

A new family of plant transcription factors displays a novel ssDNA-binding surface., Desveaux D, Allard J, Brisson N, Sygusch J, Nat Struct Biol. 2002 Jul;9(7):512-7. PMID:12080340

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