1l3e: Difference between revisions

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[[Image:1l3e.gif|left|200px]]
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[[Image:1l3e.png|left|200px]]


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{{STRUCTURE_1l3e|  PDB=1l3e  |  SCENE=  }}  
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'''NMR Structures of the HIF-1alpha CTAD/p300 CH1 Complex'''
===NMR Structures of the HIF-1alpha CTAD/p300 CH1 Complex===




==Overview==
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Adaptation to hypoxia is mediated by transactivation of hypoxia-responsive genes by hypoxia-inducible factor-1 (HIF-1) in complex with the CBP and p300 transcriptional coactivators. We report the solution structure of the cysteine/histidine-rich 1 (CH1) domain of p300 bound to the C-terminal transactivation domain of HIF-1 alpha. CH1 has a triangular geometry composed of four alpha-helices with three intervening Zn(2+)-coordinating centers. CH1 serves as a scaffold for folding of the HIF-1 alpha C-terminal transactivation domain, which forms a vise-like clamp on the CH1 domain that is stabilized by extensive hydrophobic and polar interactions. The structure reveals the mechanism of specific recognition of p300 by HIF-1 alpha, and shows how HIF-1 alpha transactivation is regulated by asparagine hydroxylation.
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{{ABSTRACT_PUBMED_11959990}}


==About this Structure==
==About this Structure==
1L3E is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L3E OCA].  
1L3E is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L3E OCA].  


==Reference==
==Reference==
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[[Category: Wagner, G.]]
[[Category: Wagner, G.]]
[[Category: Protein-protein complex]]
[[Category: Protein-protein complex]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:29:40 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 11:36:57 2008''

Revision as of 08:37, 2 July 2008

File:1l3e.png

Template:STRUCTURE 1l3e

NMR Structures of the HIF-1alpha CTAD/p300 CH1 Complex

Template:ABSTRACT PUBMED 11959990

About this Structure

1L3E is a Protein complex structure of sequences from Homo sapiens. Full experimental information is available from OCA.

Reference

Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha., Freedman SJ, Sun ZY, Poy F, Kung AL, Livingston DM, Wagner G, Eck MJ, Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5367-72. PMID:11959990

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