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| [[Image:1l7c.gif|left|200px]] | | {{Seed}} |
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| {{STRUCTURE_1l7c| PDB=1l7c | SCENE= }} | | {{STRUCTURE_1l7c| PDB=1l7c | SCENE= }} |
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| '''alpha-catenin fragment, residues 385-651'''
| | ===alpha-catenin fragment, residues 385-651=== |
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| ==Overview==
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| alpha-Catenin is an integral component of adherens junctions, where it links cadherins to the actin cytoskeleton. alpha-Catenin is also required for the colocalization of the nectin/afadin/ponsin adhesion system to adherens junctions, and it specifically associates with the nectin-binding protein afadin. A proteolytic fragment of alpha-catenin, residues 385-651, contains the afadin-binding site. The three-dimensional structure of this fragment comprises two side-by-side four-helix bundles, both of which are required for afadin binding. The alpha-catenin fragment 385-651 binds afadin more strongly than the full-length protein, suggesting that the full-length protein harbors a cryptic binding site for afadin. Comparison of the alpha-catenin 385-651 structure with the recently solved structure of the alpha-catenin M-fragment (Yang, J., Dokurno, P., Tonks, N. K., and Barford, D. (2001) EMBO J. 20, 3645-3656) reveals a surprising flexibility in the orientation of the two four-helix bundles. alpha-Catenin and the actin-binding protein vinculin share sequence and most likely structural similarity within their actin-binding domains. Despite this homology, actin binding requires additional sequences adjacent to this region.
| | The line below this paragraph, {{ABSTRACT_PUBMED_11907041}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 11907041 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_11907041}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Weis, W I.]] | | [[Category: Weis, W I.]] |
| [[Category: Four-helix bundle]] | | [[Category: Four-helix bundle]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:37:20 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 11:51:49 2008'' |
