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| {{STRUCTURE_1la6| PDB=1la6 | SCENE= }} | | {{STRUCTURE_1la6| PDB=1la6 | SCENE= }} |
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| '''The crystal structure of Trematomus newnesi hemoglobin in a partial hemichrome state'''
| | ===The crystal structure of Trematomus newnesi hemoglobin in a partial hemichrome state=== |
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| ==Overview==
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| Tetrameric hemoglobins are the most widely used systems in studying protein cooperativity. Allosteric effects in hemoglobins arise from the switch between a relaxed (R) state and a tense (T) state occurring upon oxygen release. Here we report the 2.0-A crystal structure of the main hemoglobin component of the Antarctic fish Trematomus newnesi, in a partial hemichrome form. The two alpha-subunit iron atoms are bound to a CO molecule, whereas in the beta subunits the distal histidine residue is the sixth ligand of the heme iron. This structure, a tetrameric hemoglobin in the hemichrome state, demonstrates that the iron coordination by the distal histidine, usually associated with denaturing states, may be tolerated in a native-like hemoglobin structure. In addition, several features of the tertiary and quaternary organization of this structure are intermediate between the R and T states and agree well with the R --> T transition state properties obtained by spectroscopic and kinetic techniques. The analysis of this structure provides a detailed pathway of heme-heme communication and it indicates that the plasticity of the beta heme pocket plays a role in the R --> T transition of tetrameric hemoglobins.
| | The line below this paragraph, {{ABSTRACT_PUBMED_12093902}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 12093902 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_12093902}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Bishistidine complex]] | | [[Category: Bishistidine complex]] |
| [[Category: Hemichrome]] | | [[Category: Hemichrome]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:43:07 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 12:05:59 2008'' |
