1lat: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,332,843 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,332,843 edits
No edit summary
Line 1: Line 1:
[[Image:1lat.gif|left|200px]]
{{Seed}}
[[Image:1lat.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1lat|  PDB=1lat  |  SCENE=  }}  
{{STRUCTURE_1lat|  PDB=1lat  |  SCENE=  }}  


'''GLUCOCORTICOID RECEPTOR MUTANT/DNA COMPLEX'''
===GLUCOCORTICOID RECEPTOR MUTANT/DNA COMPLEX===




==Overview==
<!--  
Steroid receptors recognize bipartite targets composed of six base-pair half-sites. There are two canonical types of half-site which differ only in their central two base pairs. The crystal structure of an estrogen receptor-like DNA-binding domain bound to the wrong type of half-site (a glucocorticoid response element) reveals an interface that resembles the specific interfaces of the glucocorticoid receptor or estrogen receptor bound to their correct response elements. The underlying stereochemical defect that weakens the non-cognate interface is a difference in the helical geometry of the incorrect DNA half-site which prevents a side-chain contact and results in a gap which is filled by at least five additional fixed water sites, imposing a potential entropic burden on the stability of the interface.
The line below this paragraph, {{ABSTRACT_PUBMED_7664096}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 7664096 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_7664096}}


==About this Structure==
==About this Structure==
Line 26: Line 30:
[[Category: Dna binding regulatory protein]]
[[Category: Dna binding regulatory protein]]
[[Category: Glucocorticoid receptor]]
[[Category: Glucocorticoid receptor]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:43:59 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 12:08:43 2008''
Retrieved from "https://proteopedia.org/1lat"