1lbc: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
Line 1: Line 1:
[[Image:1lbc.gif|left|200px]]
{{Seed}}
[[Image:1lbc.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1lbc|  PDB=1lbc  |  SCENE=  }}  
{{STRUCTURE_1lbc|  PDB=1lbc  |  SCENE=  }}  


'''Crystal structure of GluR2 ligand binding core (S1S2J-N775S) in complex with cyclothiazide (CTZ) as well as glutamate at 1.8 A resolution'''
===Crystal structure of GluR2 ligand binding core (S1S2J-N775S) in complex with cyclothiazide (CTZ) as well as glutamate at 1.8 A resolution===




==Overview==
<!--  
Ligand-gated ion channels transduce chemical signals into electrical impulses by opening a transmembrane pore in response to binding one or more neurotransmitter molecules. After activation, many ligand-gated ion channels enter a desensitized state in which the neurotransmitter remains bound but the ion channel is closed. Although receptor desensitization is crucial to the functioning of many ligand-gated ion channels in vivo, the molecular basis of this important process has until now defied analysis. Using the GluR2 AMPA-sensitive glutamate receptor, we show here that the ligand-binding cores form dimers and that stabilization of the intradimer interface by either mutations or allosteric modulators reduces desensitization. Perturbations that destabilize the interface enhance desensitization. Receptor activation involves conformational changes within each subunit that result in an increase in the separation of portions of the receptor that are linked to the ion channel. Our analysis defines the dimer interface in the resting and activated state, indicates how ligand binding is coupled to gating, and suggests modes of dimer dimer interaction in the assembled tetramer. Desensitization occurs through rearrangement of the dimer interface, which disengages the agonist-induced conformational change in the ligand-binding core from the ion channel gate.
The line below this paragraph, {{ABSTRACT_PUBMED_12015593}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 12015593 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_12015593}}


==About this Structure==
==About this Structure==
Line 37: Line 41:
[[Category: Point mutation]]
[[Category: Point mutation]]
[[Category: S1s2]]
[[Category: S1s2]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:45:09 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 12:13:23 2008''

Revision as of 09:13, 2 July 2008

File:1lbc.png

Template:STRUCTURE 1lbc

Crystal structure of GluR2 ligand binding core (S1S2J-N775S) in complex with cyclothiazide (CTZ) as well as glutamate at 1.8 A resolution

Template:ABSTRACT PUBMED 12015593

About this Structure

1LBC is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Mechanism of glutamate receptor desensitization., Sun Y, Olson R, Horning M, Armstrong N, Mayer M, Gouaux E, Nature. 2002 May 16;417(6886):245-53. PMID:12015593

Page seeded by OCA on Wed Jul 2 12:13:23 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=1lbc&oldid=624778"