1lbd: Difference between revisions

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[[Image:1lbd.~~gif~~|left|200px]]

[[Image:1lbd.png|left|200px]]

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~~'''~~LIGAND-BINDING DOMAIN OF THE HUMAN NUCLEAR RECEPTOR RXR-ALPHA~~'''~~

===LIGAND-BINDING DOMAIN OF THE HUMAN NUCLEAR RECEPTOR RXR-ALPHA===

~~==Overview==~~

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The ~~crystal structure of~~ the ~~human retinoid-X receptor RXR-alpha ligand-binding domain reveals a previously undiscovered fold of an antiparallel alpha-helical sandwich, packed~~ as ~~dimeric units~~. ~~Two helices and one loop form the homodimerization surface~~, ~~and hydrophobic heptad repeats participate in stabilizing~~ the ~~fold~~. ~~The existence of a ligand~~-~~binding pocket is proposed that would allow 9~~-cis retinoic acid to interact with different functional modules, including the AF-2 activating domain. Several lines of evidence indicate that the overall structure is a prototype fold of ligand-binding domains of nuclear receptors.

The line below this paragraph, {{ABSTRACT_PUBMED_7760929}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 7760929 is the PubMed ID number.

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==About this Structure==

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[[Category: Structural proteomics in europe]]

[[Category: Transcription factor]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun Apr~~ 13 ~~08:07~~:08 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 12:13:48 2008''

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-[[Image:1lbd.gif|left|200px]]
+{{Seed}}
+[[Image:1lbd.png|left|200px]]
 <!--
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 {{STRUCTURE_1lbd|  PDB=1lbd  |  SCENE=  }}
-'''LIGAND-BINDING DOMAIN OF THE HUMAN NUCLEAR RECEPTOR RXR-ALPHA'''
+===LIGAND-BINDING DOMAIN OF THE HUMAN NUCLEAR RECEPTOR RXR-ALPHA===
-==Overview==
+<!--
-The crystal structure of the human retinoid-X receptor RXR-alpha ligand-binding domain reveals a previously undiscovered fold of an antiparallel alpha-helical sandwich, packed as dimeric units. Two helices and one loop form the homodimerization surface, and hydrophobic heptad repeats participate in stabilizing the fold. The existence of a ligand-binding pocket is proposed that would allow 9-cis retinoic acid to interact with different functional modules, including the AF-2 activating domain. Several lines of evidence indicate that the overall structure is a prototype fold of ligand-binding domains of nuclear receptors.
+The line below this paragraph, {{ABSTRACT_PUBMED_7760929}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 7760929 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_7760929}}
 ==About this Structure==
@@ Line 30: / Line 34: @@
 [[Category: Structural proteomics in europe]]
 [[Category: Transcription factor]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Apr 13 08:07:08 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul  2 12:13:48 2008''