1lc6: Difference between revisions

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[[Image:1lc6.~~gif~~|left|200px]]

[[Image:1lc6.png|left|200px]]

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~~'''~~Solution Structure of the U6 Intramolecular Stem-loop RNA~~'''~~

===Solution Structure of the U6 Intramolecular Stem-loop RNA===

~~==Overview==~~

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~~U6 RNA is a key component of~~ the ~~catalytic core of the spliceosome. A metal ion essential for the first catalytic step of pre-mRNA splicing binds~~ to the ~~U80 Sp phosphate oxygen within the yeast U6 intramolecular stem-loop~~ (~~ISL~~)~~. Here we present the first structural data for U6 RNA~~, ~~revealing~~ the ~~three~~-~~dimensional structure of the highly conserved U6 ISL. The ISL binds metal ion at the U80 site with the same stereo specificity as the intact spliceosome. The metal~~-binding site is adjacent to a readily protonated C.A wobble pair. Protonation of the C.A pair and metal binding are mutually antagonistic. These results support a ribozyme model for U6 RNA function and suggest a possible mechanism for the regulation of RNA splicing.

The line below this paragraph, {{ABSTRACT_PUBMED_11992125}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 11992125 is the PubMed ID number.

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==About this Structure==

Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LC6 OCA].

Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LC6 OCA].

==Reference==

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[[Category: Rna]]

[[Category: Stem-loop]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May~~ 2 23:46:49 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 12:19:13 2008''

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-[[Image:1lc6.gif|left|200px]]
+{{Seed}}
+[[Image:1lc6.png|left|200px]]
 <!--
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 {{STRUCTURE_1lc6|  PDB=1lc6  |  SCENE=  }}
-'''Solution Structure of the U6 Intramolecular Stem-loop RNA'''
+===Solution Structure of the U6 Intramolecular Stem-loop RNA===
-==Overview==
+<!--
-U6 RNA is a key component of the catalytic core of the spliceosome. A metal ion essential for the first catalytic step of pre-mRNA splicing binds to the U80 Sp phosphate oxygen within the yeast U6 intramolecular stem-loop (ISL). Here we present the first structural data for U6 RNA, revealing the three-dimensional structure of the highly conserved U6 ISL. The ISL binds metal ion at the U80 site with the same stereo specificity as the intact spliceosome. The metal-binding site is adjacent to a readily protonated C.A wobble pair. Protonation of the C.A pair and metal binding are mutually antagonistic. These results support a ribozyme model for U6 RNA function and suggest a possible mechanism for the regulation of RNA splicing.
+The line below this paragraph, {{ABSTRACT_PUBMED_11992125}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 11992125 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_11992125}}
 ==About this Structure==
-Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LC6 OCA].
+Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LC6 OCA].
 ==Reference==
@@ Line 28: / Line 32: @@
 [[Category: Rna]]
 [[Category: Stem-loop]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 23:46:49 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul  2 12:19:13 2008''