1lcs: Difference between revisions

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[[Image:1lcs.gif|left|200px]]
{{Seed}}
[[Image:1lcs.png|left|200px]]


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{{STRUCTURE_1lcs|  PDB=1lcs  |  SCENE=  }}  
{{STRUCTURE_1lcs|  PDB=1lcs  |  SCENE=  }}  


'''RECEPTOR-BINDING DOMAIN FROM SUBGROUP B FELINE LEUKEMIA VIRUS'''
===RECEPTOR-BINDING DOMAIN FROM SUBGROUP B FELINE LEUKEMIA VIRUS===




==Overview==
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Infection of T lymphocytes by the cytopathic retrovirus feline leukemia virus subgroup T (FeLV-T) requires FeLIX, a cellular coreceptor that is encoded by an endogenous provirus and closely resembles the receptor-binding domain (RBD) of feline leukemia virus subgroup B (FeLV-B). We determined the structure of FeLV-B RBD, which has FeLIX activity, to a 2.5-A resolution by X-ray crystallography. The structure of the receptor-specific subdomain of this glycoprotein differs dramatically from that of Friend murine leukemia virus (Fr-MLV), which binds a different cell surface receptor. Remarkably, we find that Fr-MLV RBD also activates FeLV-T infection of cells expressing the Fr-MLV receptor and that FeLV-B RBD is a competitive inhibitor of infection under these conditions. These studies suggest that FeLV-T infection relies on the following property of mammalian leukemia virus RBDs: the ability to couple interaction with one of a variety of receptors to the activation of a conserved membrane fusion mechanism. A comparison of the FeLV-B and Fr-MLV RBD structures illustrates how receptor-specific regions are linked to conserved elements critical for postbinding events in virus entry.
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{{ABSTRACT_PUBMED_12552012}}


==About this Structure==
==About this Structure==
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[[Category: Wensel, D L.]]
[[Category: Wensel, D L.]]
[[Category: Antiparallel beta-sandwich glycoprotein]]
[[Category: Antiparallel beta-sandwich glycoprotein]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:47:38 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 12:23:16 2008''

Revision as of 09:23, 2 July 2008

File:1lcs.png

Template:STRUCTURE 1lcs

RECEPTOR-BINDING DOMAIN FROM SUBGROUP B FELINE LEUKEMIA VIRUS

Template:ABSTRACT PUBMED 12552012

About this Structure

1LCS is a Single protein structure of sequence from Viruses. Full crystallographic information is available from OCA.

Reference

Structure and mechanism of a coreceptor for infection by a pathogenic feline retrovirus., Barnett AL, Wensel DL, Li W, Fass D, Cunningham JM, J Virol. 2003 Feb;77(4):2717-29. PMID:12552012

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