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| [[Image:1lit.gif|left|200px]] | | {{Seed}} |
| | [[Image:1lit.png|left|200px]] |
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| {{STRUCTURE_1lit| PDB=1lit | SCENE= }} | | {{STRUCTURE_1lit| PDB=1lit | SCENE= }} |
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| '''HUMAN LITHOSTATHINE'''
| | ===HUMAN LITHOSTATHINE=== |
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| ==Overview==
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| Human lithostathine (HLIT) is a pancreatic glycoprotein which inhibits the growth and nucleation of calcium carbonate crystals. The crystal structure of the monomeric 17 kDa HLIT, determined to a resolution of 1.55 angstroms, was refined to a crystallographic R-factor of 18.6%. Structural comparison with the carbohydrate-recognition domains of rat mannose-binding protein and E-selectin indicates that the C-terminal domain of HLIT shares a common architecture with the C-type lectins. Nevertheless, HLIT does not bind carbohydrate nor does it contain the characteristic calcium-binding sites of the C-type lectins. In consequence, HLIT represents the first structurally characterized member of this superfamily which is not a lectin. Analysis of the charge distribution and calculation of its dipole moment reveal that HLIT is a strongly polarized molecule. Eight acidic residues which are separated by regular 6 angstrom spacings form a unique and continuous patch on the molecular surface. This arrangement coincides with the distribution of calcium ions on certain planes of the calcium carbonate crystal; the dipole moment of HLIT may play a role in orienting the protein on the crystal surface prior to the more specific interactions of the acidic residues.
| | The line below this paragraph, {{ABSTRACT_PUBMED_8654365}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 8654365 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_8654365}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Lectin]] | | [[Category: Lectin]] |
| [[Category: Pancreatic stone inhibitor]] | | [[Category: Pancreatic stone inhibitor]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:57:49 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 20:59:42 2008'' |
