2jtm: Difference between revisions

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[[Image:2jtm.jpg|left|200px]]
{{Seed}}
[[Image:2jtm.png|left|200px]]


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{{STRUCTURE_2jtm|  PDB=2jtm  |  SCENE=  }}  
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'''Solution structure of Sso6901 from Sulfolobus solfataricus P2'''
===Solution structure of Sso6901 from Sulfolobus solfataricus P2===




==Overview==
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Archaea contain a variety of chromatin proteins consistent with the evolution of different genome packaging mechanisms. Among the two main kingdoms in the Archaea, Euryarchaeota synthesize histone homologs, whereas Crenarchaeota have not been shown to possess a chromatin protein conserved at the kingdom level. We report the identification of Cren7, a novel family of chromatin proteins highly conserved in the Crenarchaeota. A small, basic, methylated and abundant protein, Cren7 displays a higher affinity for double-stranded DNA than for single-stranded DNA, constrains negative DNA supercoils and is associated with genomic DNA in vivo. The solution structure and DNA-binding surface of Cren7 from the hyperthermophilic crenarchaeon Sulfolobus solfataricus were determined by NMR. The protein adopts an SH3-like fold. It interacts with duplex DNA through a beta-sheet and a long flexible loop, presumably resulting in DNA distortions through intercalation of conserved hydrophobic residues into the DNA structure. These data suggest that the crenarchaeal kingdom in the Archaea shares a common strategy in chromatin organization.
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{{ABSTRACT_PUBMED_18096617}}


==About this Structure==
==About this Structure==
2JTM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JTM OCA].  
2JTM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JTM OCA].  


==Reference==
==Reference==
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[[Category: Huang, L.]]
[[Category: Huang, L.]]
[[Category: Wang, J.]]
[[Category: Wang, J.]]
[[Category: Dna binding protein]]
[[Category: Sh3-like]]
[[Category: Sh3-like]]
[[Category: Unknown function]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 30 12:49:38 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul  2 20:59:58 2008''

Revision as of 17:59, 2 July 2008

File:2jtm.png

Template:STRUCTURE 2jtm

Solution structure of Sso6901 from Sulfolobus solfataricus P2

Template:ABSTRACT PUBMED 18096617

About this Structure

2JTM is a Single protein structure of sequence from Sulfolobus solfataricus. Full experimental information is available from OCA.

Reference

Biochemical and structural characterization of Cren7, a novel chromatin protein conserved among Crenarchaea., Guo L, Feng Y, Zhang Z, Yao H, Luo Y, Wang J, Huang L, Nucleic Acids Res. 2008 Mar;36(4):1129-37. Epub 2007 Dec 20. PMID:18096617

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