1lk0: Difference between revisions

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[[Image:1lk0.jpg|left|200px]]
{{Seed}}
[[Image:1lk0.png|left|200px]]


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{{STRUCTURE_1lk0|  PDB=1lk0  |  SCENE=  }}  
{{STRUCTURE_1lk0|  PDB=1lk0  |  SCENE=  }}  


'''Disulfide intermediate of C89L Arsenate reductase from pI258'''
===Disulfide intermediate of C89L Arsenate reductase from pI258===




==Overview==
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The mechanism of pI258 arsenate reductase (ArsC) catalyzed arsenate reduction, involving its P-loop structural motif and three redox active cysteines, has been unraveled. All essential intermediates are visualized with x-ray crystallography, and NMR is used to map dynamic regions in a key disulfide intermediate. Steady-state kinetics of ArsC mutants gives a view of the crucial residues for catalysis. ArsC combines a phosphatase-like nucleophilic displacement reaction with a unique intramolecular disulfide bond cascade. Within this cascade, the formation of a disulfide bond triggers a reversible "conformational switch" that transfers the oxidative equivalents to the surface of the protein, while releasing the reduced substrate.
The line below this paragraph, {{ABSTRACT_PUBMED_12072565}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_12072565}}


==About this Structure==
==About this Structure==
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[[Category: P-loop]]
[[Category: P-loop]]
[[Category: Ptpase i fold]]
[[Category: Ptpase i fold]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:59:40 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 21:16:05 2008''
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