1lm7: Difference between revisions

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[[Image:1lm7.gif|left|200px]]
{{Seed}}
[[Image:1lm7.png|left|200px]]


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{{STRUCTURE_1lm7|  PDB=1lm7  |  SCENE=  }}  
{{STRUCTURE_1lm7|  PDB=1lm7  |  SCENE=  }}  


'''Structures of two intermediate filament-binding fragments of desmoplakin reveal a unique repeat motif structure'''
===Structures of two intermediate filament-binding fragments of desmoplakin reveal a unique repeat motif structure===




==Overview==
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Desmosomes are intercellular junctions in which cadherin cell adhesion molecules are linked to the intermediate filament (IF) system. Desmoplakin is a member of the plakin family of IF-binding proteins. The C-terminal domain of desmoplakin (DPCT) mediates binding to IFs in desmosomes. The DPCT sequence contains three regions, termed A, B and C, consisting of 4.5 copies of a 38-amino acid repeat motif. We demonstrate that these regions form discrete subdomains that bind to IFs and report the crystal structures of domains B and C. In contrast to the elongated structures formed by other kinds of repeat motifs, the plakin repeats form a globular structure with a unique fold. A conserved basic groove found on the domain may represent an IF-binding site.
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{{ABSTRACT_PUBMED_12101406}}


==About this Structure==
==About this Structure==
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[[Category: Weis, W I.]]
[[Category: Weis, W I.]]
[[Category: Plakin repeat]]
[[Category: Plakin repeat]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:03:30 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 21:24:44 2008''

Revision as of 18:24, 2 July 2008

File:1lm7.png

Template:STRUCTURE 1lm7

Structures of two intermediate filament-binding fragments of desmoplakin reveal a unique repeat motif structure

Template:ABSTRACT PUBMED 12101406

About this Structure

1LM7 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structures of two intermediate filament-binding fragments of desmoplakin reveal a unique repeat motif structure., Choi HJ, Park-Snyder S, Pascoe LT, Green KJ, Weis WI, Nat Struct Biol. 2002 Aug;9(8):612-20. PMID:12101406

Page seeded by OCA on Wed Jul 2 21:24:44 2008

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