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[[Image:1lnw.gif|left|200px]]
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[[Image:1lnw.png|left|200px]]


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{{STRUCTURE_1lnw|  PDB=1lnw  |  SCENE=  }}  
{{STRUCTURE_1lnw|  PDB=1lnw  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF THE MEXR REPRESSOR OF THE MEXAB-OPRM MULTIDRUG EFFLUX OPERON OF PSEUDOMONAS AERUGINOSA'''
===CRYSTAL STRUCTURE OF THE MEXR REPRESSOR OF THE MEXAB-OPRM MULTIDRUG EFFLUX OPERON OF PSEUDOMONAS AERUGINOSA===




==Overview==
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MexR is a member of the MarR family of bacterial transcriptional regulators and is the repressor for the MexAB-OprM operon, which encodes a tripartite multidrug efflux system in Pseudomonas aeruginosa. Mutations in MexR result in increased resistance to multiple antibiotics due to overexpression of this efflux system. We have determined the crystal structure of MexR to 2.1-A resolution in the absence of effector. The four copies of the MexR dimer in the asymmetric unit are observed in multiple conformations. Analysis of these conformational states in the context of a model of the MexR-DNA complex proposed in this study suggests that an effector-induced conformational change may inhibit DNA binding by reducing the spacing of the DNA binding domains. The inhibited conformation is exhibited by one of the four MexR dimers, which contains an ordered C-terminal tail from a neighboring monomer inserted between its DNA binding domains and which we propose may resemble the MexR-effector complex. Our results indicate that MexR may differ from the other described member of this family, MarR, in the nature of its effector, mode of DNA binding, and mechanism of regulation.
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{{ABSTRACT_PUBMED_12034710}}


==About this Structure==
==About this Structure==
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[[Category: Regulator of mexrab-oprm operon]]
[[Category: Regulator of mexrab-oprm operon]]
[[Category: Repressor]]
[[Category: Repressor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 21:31:46 2008''

Revision as of 18:31, 2 July 2008

File:1lnw.png

Template:STRUCTURE 1lnw

CRYSTAL STRUCTURE OF THE MEXR REPRESSOR OF THE MEXAB-OPRM MULTIDRUG EFFLUX OPERON OF PSEUDOMONAS AERUGINOSA

Template:ABSTRACT PUBMED 12034710

About this Structure

1LNW is a Single protein structure of sequence from Pseudomonas aeruginosa. Full crystallographic information is available from OCA.

Reference

Crystal structure of the MexR repressor of the mexRAB-oprM multidrug efflux operon of Pseudomonas aeruginosa., Lim D, Poole K, Strynadka NC, J Biol Chem. 2002 Aug 9;277(32):29253-9. Epub 2002 May 28. PMID:12034710

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