1lo5: Difference between revisions

Line 1:

[[Image:1lo5.~~gif~~|left|200px]]

[[Image:1lo5.png|left|200px]]

<!--

Line 9:

Line 10:

~~'''~~Crystal structure of the D227A variant of Staphylococcal enterotoxin A in complex with human MHC class II~~'''~~

===Crystal structure of the D227A variant of Staphylococcal enterotoxin A in complex with human MHC class II===

~~==Overview==~~

<!--

~~Although the biological properties of staphylococcal enterotoxin A (SEA) have been well characterized~~, ~~structural insights into the interaction between SEA and major histocompatibilty complex (MHC) class II have only been obtained by modeling. Here~~, the ~~crystal structure of~~ the ~~D227A variant of SEA in complex with human MHC class II has been determined by X-ray crystallography. SEA~~(~~D227A) exclusively binds with its N-terminal domain to the alpha chain of HLA-DR1~~. ~~The ability of one SEA molecule to crosslink two MHC molecules was modeled~~. ~~It shows that this SEA molecule cannot interact with the T cell receptor (TCR~~) ~~while a second SEA molecule interacts with MHC. Because of its relatively low toxicity~~, the ~~D227A variant of SEA is used in tumor therapy~~.

The line below this paragraph, {{ABSTRACT_PUBMED_12467569}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 12467569 is the PubMed ID number.

-->

==About this Structure==

Line 28:

Line 32:

[[Category: Walse, B.]]

[[Category: Protein-protein complex]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May~~ ~~3 00~~:06:35 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 21:33:36 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:1lo5.gif|left|200px]]
+{{Seed}}
+[[Image:1lo5.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1lo5|  PDB=1lo5  |  SCENE=  }}
-'''Crystal structure of the D227A variant of Staphylococcal enterotoxin A in complex with human MHC class II'''
+===Crystal structure of the D227A variant of Staphylococcal enterotoxin A in complex with human MHC class II===
-==Overview==
+<!--
-Although the biological properties of staphylococcal enterotoxin A (SEA) have been well characterized, structural insights into the interaction between SEA and major histocompatibilty complex (MHC) class II have only been obtained by modeling. Here, the crystal structure of the D227A variant of SEA in complex with human MHC class II has been determined by X-ray crystallography. SEA(D227A) exclusively binds with its N-terminal domain to the alpha chain of HLA-DR1. The ability of one SEA molecule to crosslink two MHC molecules was modeled. It shows that this SEA molecule cannot interact with the T cell receptor (TCR) while a second SEA molecule interacts with MHC. Because of its relatively low toxicity, the D227A variant of SEA is used in tumor therapy.
+The line below this paragraph, {{ABSTRACT_PUBMED_12467569}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 12467569 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_12467569}}
 ==About this Structure==
@@ Line 28: / Line 32: @@
 [[Category: Walse, B.]]
 [[Category: Protein-protein complex]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 00:06:35 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul  2 21:33:36 2008''