1lpd: Difference between revisions

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[[Image:1lpd.gif|left|200px]]
{{Seed}}
[[Image:1lpd.png|left|200px]]


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{{STRUCTURE_1lpd|  PDB=1lpd  |  SCENE=  }}  
{{STRUCTURE_1lpd|  PDB=1lpd  |  SCENE=  }}  


'''HIGH RESOLUTION STRUCTURE OF RECOMBINANT DIANTHIN ANTIVIRAL PROTEIN-POTENT ANTI-HIV AGENT (COMPLEX WITH ADENINE)'''
===HIGH RESOLUTION STRUCTURE OF RECOMBINANT DIANTHIN ANTIVIRAL PROTEIN-POTENT ANTI-HIV AGENT (COMPLEX WITH ADENINE)===




==Overview==
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Dianthin antiviral protein (DAP) is a naturally occurring antiviral protein from the leaves of carnation (Dianthus caryophyllus) capable of depurinating HIV-1 RNA and inhibiting HIV-1 replication in human peripheral blood mononuclear cells. Escherichia coli-derived recombinant DAP (rDAP, amino acids 1-254) was purified to homogeneity for structural and functional studies. In the following paper the X-ray crystal structure of rDAP as well as its complexes with cyclic AMP and adenyl-guanosine (ApG) as substrate analogs at 1.7 A resolution are reported. Molecular modeling studies of the interactions of DAP and the structurally similar pokeweed antiviral protein (PAP) with a single-stranded RNA heptamer predicted a more potent anti-HIV activity for rDAP due to its unique surface topology and more favorable charge distribution in its 20 A-long RNA binding active center cleft. In accordance with the predictions of the modeling studies, rDAP was more potent than rPAP in depurinating HIV-1 RNA. To the knowledge of the authors, this is the first structural and functional characterization of recombinant DAP.
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{{ABSTRACT_PUBMED_15553110}}


==About this Structure==
==About this Structure==
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[[Category: Polynucleotide:adenosine glycosidase]]
[[Category: Polynucleotide:adenosine glycosidase]]
[[Category: Ribosome inactivating protein]]
[[Category: Ribosome inactivating protein]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:08:51 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 21:42:41 2008''

Revision as of 18:42, 2 July 2008

File:1lpd.png

Template:STRUCTURE 1lpd

HIGH RESOLUTION STRUCTURE OF RECOMBINANT DIANTHIN ANTIVIRAL PROTEIN-POTENT ANTI-HIV AGENT (COMPLEX WITH ADENINE)

Template:ABSTRACT PUBMED 15553110

About this Structure

1LPD is a Single protein structure of sequence from Dianthus caryophyllus. Full crystallographic information is available from OCA.

Reference

High resolution X-ray structure and potent anti-HIV activity of recombinant dianthin antiviral protein., Kurinov IV, Rajamohan F, Uckun FM, Arzneimittelforschung. 2004;54(10):692-702. PMID:15553110

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