1lpe: Difference between revisions

Line 1:

[[Image:1lpe.~~jpg~~|left|200px]]

[[Image:1lpe.png|left|200px]]

<!--

Line 9:

Line 10:

~~'''~~THREE-DIMENSIONAL STRUCTURE OF THE LDL RECEPTOR-BINDING DOMAIN OF HUMAN APOLIPOPROTEIN E~~'''~~

===THREE-DIMENSIONAL STRUCTURE OF THE LDL RECEPTOR-BINDING DOMAIN OF HUMAN APOLIPOPROTEIN E===

~~==Overview==~~

<!--

~~Human apolipoprotein E~~, ~~a blood plasma protein~~, ~~mediates~~ the ~~transport and uptake of cholesterol and lipid by way of its high affinity interaction with different cellular receptors, including~~ the ~~low-density lipoprotein~~ (~~LDL) receptor. The three-dimensional structure of the LDL receptor-binding domain of apoE has been determined~~ at 2.~~5 angstrom resolution by x-ray crystallography~~. ~~The protein forms an unusually elongated (65 angstroms~~) ~~four-helix bundle~~, ~~with~~ the ~~helices apparently stabilized by a tightly packed hydrophobic core that includes leucine zipper~~-type interactions and by numerous salt bridges on the mostly charged surface. Basic amino acids important for LDL receptor binding are clustered into a surface patch on one long helix. This structure provides the basis for understanding the behavior of naturally occurring mutants that can lead to atherosclerosis.

The line below this paragraph, {{ABSTRACT_PUBMED_2063194}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 2063194 is the PubMed ID number.

-->

==About this Structure==

Line 25:

Line 29:

[[Category: Wilson, C.]]

[[Category: Lipoprotein]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May~~ ~~3 00~~:08:50 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 21:42:49 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:1lpe.jpg|left|200px]]
+{{Seed}}
+[[Image:1lpe.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1lpe|  PDB=1lpe  |  SCENE=  }}
-'''THREE-DIMENSIONAL STRUCTURE OF THE LDL RECEPTOR-BINDING DOMAIN OF HUMAN APOLIPOPROTEIN E'''
+===THREE-DIMENSIONAL STRUCTURE OF THE LDL RECEPTOR-BINDING DOMAIN OF HUMAN APOLIPOPROTEIN E===
-==Overview==
+<!--
-Human apolipoprotein E, a blood plasma protein, mediates the transport and uptake of cholesterol and lipid by way of its high affinity interaction with different cellular receptors, including the low-density lipoprotein (LDL) receptor. The three-dimensional structure of the LDL receptor-binding domain of apoE has been determined at 2.5 angstrom resolution by x-ray crystallography. The protein forms an unusually elongated (65 angstroms) four-helix bundle, with the helices apparently stabilized by a tightly packed hydrophobic core that includes leucine zipper-type interactions and by numerous salt bridges on the mostly charged surface. Basic amino acids important for LDL receptor binding are clustered into a surface patch on one long helix. This structure provides the basis for understanding the behavior of naturally occurring mutants that can lead to atherosclerosis.
+The line below this paragraph, {{ABSTRACT_PUBMED_2063194}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 2063194 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_2063194}}
 ==About this Structure==
@@ Line 25: / Line 29: @@
 [[Category: Wilson, C.]]
 [[Category: Lipoprotein]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 00:08:50 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul  2 21:42:49 2008''