1lti: Difference between revisions

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[[Image:1lti.~~jpg~~|left|200px]]

[[Image:1lti.png|left|200px]]

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~~'''~~HEAT-LABILE ENTEROTOXIN (LT-I) COMPLEX WITH T-ANTIGEN~~'''~~

===HEAT-LABILE ENTEROTOXIN (LT-I) COMPLEX WITH T-ANTIGEN===

~~==Overview==~~

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~~Heat-labile enterotoxin (LT) is part of~~ the ~~cholera toxin (CT) family and consists of a catalytic A subunit and a B pentamer that serves~~ to ~~recognize~~ the ~~oligosaccharide part of the GM1 ganglioside receptor. We report here the crystal structure of heat-labile enterotoxin in complex with the disaccharide portion of the Thomsen-Friedenreich~~ (~~T-antigen) tumor marker. The toxin~~:~~carbohydrate complex is determined to 2~~.~~13 A resolution, yielding an R-factor of 18~~.~~5%. The T-antigen disaccharide, D-Gal-beta 1,3-GalNAc-Ser/Thr~~, is ~~present in more than 85% of human carcinomas and monitoring its autoimmune response is used for~~ the ~~early detection of tumors~~. ~~Insight into the molecular recognition of this tumor antigen by sugar binding proteins can benefit the development of a diagnostic tool for human carcinomas as well as a T~~-~~antigen directed anticancer drug delivery system.~~

The line below this paragraph, {{ABSTRACT_PUBMED_8762150}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 8762150 is the PubMed ID number.

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==About this Structure==

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[[Category: Adp-ribosyl transferase]]

[[Category: Enterotoxin]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May~~ ~~3 00~~:16:23 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 22:11:14 2008''

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-[[Image:1lti.jpg|left|200px]]
+{{Seed}}
+[[Image:1lti.png|left|200px]]
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 {{STRUCTURE_1lti|  PDB=1lti  |  SCENE=  }}
-'''HEAT-LABILE ENTEROTOXIN (LT-I) COMPLEX WITH T-ANTIGEN'''
+===HEAT-LABILE ENTEROTOXIN (LT-I) COMPLEX WITH T-ANTIGEN===
-==Overview==
+<!--
-Heat-labile enterotoxin (LT) is part of the cholera toxin (CT) family and consists of a catalytic A subunit and a B pentamer that serves to recognize the oligosaccharide part of the GM1 ganglioside receptor. We report here the crystal structure of heat-labile enterotoxin in complex with the disaccharide portion of the Thomsen-Friedenreich (T-antigen) tumor marker. The toxin:carbohydrate complex is determined to 2.13 A resolution, yielding an R-factor of 18.5%. The T-antigen disaccharide, D-Gal-beta 1,3-GalNAc-Ser/Thr, is present in more than 85% of human carcinomas and monitoring its autoimmune response is used for the early detection of tumors. Insight into the molecular recognition of this tumor antigen by sugar binding proteins can benefit the development of a diagnostic tool for human carcinomas as well as a T-antigen directed anticancer drug delivery system.
+The line below this paragraph, {{ABSTRACT_PUBMED_8762150}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 8762150 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_8762150}}
 ==About this Structure==
@@ Line 26: / Line 30: @@
 [[Category: Adp-ribosyl transferase]]
 [[Category: Enterotoxin]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 00:16:23 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul  2 22:11:14 2008''