1lww: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,332,843 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,332,843 edits
No edit summary
Line 1: Line 1:
[[Image:1lww.gif|left|200px]]
{{Seed}}
[[Image:1lww.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1lww|  PDB=1lww  |  SCENE=  }}  
{{STRUCTURE_1lww|  PDB=1lww  |  SCENE=  }}  


'''Borohydride-trapped hOgg1 Intermediate Structure Co-Crystallized with 8-bromoguanine'''
===Borohydride-trapped hOgg1 Intermediate Structure Co-Crystallized with 8-bromoguanine===




==Overview==
<!--  
Most spontaneous damage to bases in DNA is corrected through the action of the base-excision DNA repair pathway. Base excision repair is initiated by DNA glycosylases, lesion-specific enzymes that intercept aberrant bases in DNA and catalyze their excision. How such proteins accomplish the feat of catalyzing no fewer than five sequential reaction steps using a single active site has been unknown. To help answer this, we report the structure of a trapped catalytic intermediate in DNA repair by human 8-oxoguanine DNA glycosylase. This structure and supporting biochemical results reveal that the enzyme sequesters the excised lesion base and exploits it as a cofactor to participate in catalysis. To our knowledge, the present example represents the first documented case of product-assisted catalysis in an enzyme-catalyzed reaction.
The line below this paragraph, {{ABSTRACT_PUBMED_12592398}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 12592398 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_12592398}}


==About this Structure==
==About this Structure==
Line 34: Line 38:
[[Category: Protein/dna]]
[[Category: Protein/dna]]
[[Category: Reaction intermediate]]
[[Category: Reaction intermediate]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:23:01 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 22:43:58 2008''
Retrieved from "https://proteopedia.org/1lww"