1m0g: Difference between revisions

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[[Image:1m0g.jpg|left|200px]]
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[[Image:1m0g.png|left|200px]]


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{{STRUCTURE_1m0g|  PDB=1m0g  |  SCENE=  }}  
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'''Solution structure of the alpha domain of mt_nc'''
===Solution structure of the alpha domain of mt_nc===




==Overview==
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The structure of [113Cd(7)]-metallothionein (MT_nc) of the Antarctic fish Notothenia coriiceps, the first three-dimensional structure of a fish metallothionein, was determined by homonuclear 1H NMR experiments and heteronuclear [1H, 113Cd]-correlation spectroscopy. MT_nc is composed of an N-terminal beta domain with 9 cysteines and 3 metal ions and a carboxy-terminal alpha-domain with 11 cysteines and 4 metal ions. The position of the ninth Cys of the alpha domain of MT_nc is different from the corresponding Cys of mammalian MTs. As a result, the last CXCC motif in the mammalian MT sequence becomes CXXXCC in the fish MT. This difference leads to a structural change of the alpha domain and, in turn, to a different charge distribution with respect to that observed in mammalian metallothioneins.
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{{ABSTRACT_PUBMED_12679021}}


==About this Structure==
==About this Structure==
1M0G is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Notothenia_coriiceps Notothenia coriiceps]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M0G OCA].  
1M0G is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Notothenia_coriiceps Notothenia coriiceps]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M0G OCA].  


==Reference==
==Reference==
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[[Category: Temussi, P A.]]
[[Category: Temussi, P A.]]
[[Category: Cadmium-thiolate cluster]]
[[Category: Cadmium-thiolate cluster]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:29:00 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 22:56:37 2008''

Revision as of 19:56, 2 July 2008

File:1m0g.png

Template:STRUCTURE 1m0g

Solution structure of the alpha domain of mt_nc

Template:ABSTRACT PUBMED 12679021

About this Structure

1M0G is a Single protein structure of sequence from Notothenia coriiceps. Full experimental information is available from OCA.

Reference

Solution structure of MT_nc, a novel metallothionein from the Antarctic fish Notothenia coriiceps., Capasso C, Carginale V, Crescenzi O, Di Maro D, Parisi E, Spadaccini R, Temussi PA, Structure. 2003 Apr;11(4):435-43. PMID:12679021

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