1m6b: Difference between revisions

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[[Image:1m6b.jpg|left|200px]]
{{Seed}}
[[Image:1m6b.png|left|200px]]


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{{STRUCTURE_1m6b|  PDB=1m6b  |  SCENE=  }}  
{{STRUCTURE_1m6b|  PDB=1m6b  |  SCENE=  }}  


'''Structure of the HER3 (ERBB3) Extracellular Domain'''
===Structure of the HER3 (ERBB3) Extracellular Domain===




==Overview==
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We have determined the 2.6 angstrom crystal structure of the entire extracellular region of human HER3 (ErbB3), a member of the epidermal growth factor receptor (EGFR) family. The structure consists of four domains with structural homology to domains found in the type I insulin-like growth factor receptor. The HER3 structure reveals a contact between domains II and IV that constrains the relative orientations of ligand-binding domains and provides a structural basis for understanding both multiple-affinity forms of EGFRs and conformational changes induced in the receptor by ligand binding during signaling. These results also suggest new therapeutic approaches to modulating the behavior of members of the EGFR family.
The line below this paragraph, {{ABSTRACT_PUBMED_12154198}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 12154198 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12154198}}


==About this Structure==
==About this Structure==
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[[Category: Immunity]]
[[Category: Immunity]]
[[Category: Tyrosine kinase]]
[[Category: Tyrosine kinase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:41:13 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:18:32 2008''
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