1m6p: Difference between revisions

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[[Image:1m6p.jpg|left|200px]]
{{Seed}}
[[Image:1m6p.png|left|200px]]


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{{STRUCTURE_1m6p|  PDB=1m6p  |  SCENE=  }}  
{{STRUCTURE_1m6p|  PDB=1m6p  |  SCENE=  }}  


'''EXTRACYTOPLASMIC DOMAIN OF BOVINE CATION-DEPENDENT MANNOSE 6-PHOSPHATE RECEPTOR'''
===EXTRACYTOPLASMIC DOMAIN OF BOVINE CATION-DEPENDENT MANNOSE 6-PHOSPHATE RECEPTOR===




==Overview==
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Targeting of newly synthesized lysosomal hydrolases to the lysosome is mediated by the cation-dependent mannose 6-phosphate receptor (CD-MPR) and the insulin-like growth factor II/cation-independent mannose 6-phosphate receptor (IGF-II/CI-MPR). The two receptors, which share sequence similarities, constitute the P-type family of animal lectins. We now report the three-dimensional structure of a glycosylation-deficient, yet fully functional form of the extracytoplasmic domain of the bovine CD-MPR (residues 3-154) complexed with mannose 6-phosphate at 1.8 A resolution. The extracytoplasmic domain of the CD-MPR crystallizes as a dimer, and each monomer folds into a nine-stranded flattened beta barrel, which bears a striking resemblance to avidin. The distance of 40 A between the two ligand-binding sites of the dimer provides a structural basis for the observed differences in binding affinity exhibited by the CD-MPR toward various lysosomal enzymes.
The line below this paragraph, {{ABSTRACT_PUBMED_9604938}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 9604938 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9604938}}


==About this Structure==
==About this Structure==
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[[Category: Receptor]]
[[Category: Receptor]]
[[Category: Transport]]
[[Category: Transport]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:42:12 2008''
 
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Revision as of 20:20, 2 July 2008

File:1m6p.png

Template:STRUCTURE 1m6p

EXTRACYTOPLASMIC DOMAIN OF BOVINE CATION-DEPENDENT MANNOSE 6-PHOSPHATE RECEPTOR

Template:ABSTRACT PUBMED 9604938

About this Structure

1M6P is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Molecular basis of lysosomal enzyme recognition: three-dimensional structure of the cation-dependent mannose 6-phosphate receptor., Roberts DL, Weix DJ, Dahms NM, Kim JJ, Cell. 1998 May 15;93(4):639-48. PMID:9604938

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