1m9o: Difference between revisions

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[[Image:1m9o.gif|left|200px]]
{{Seed}}
[[Image:1m9o.png|left|200px]]


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{{STRUCTURE_1m9o|  PDB=1m9o  |  SCENE=  }}  
{{STRUCTURE_1m9o|  PDB=1m9o  |  SCENE=  }}  


'''NMR structure of the first Zinc Binding domain of Nup475/TTP/TIS11'''
===NMR structure of the first Zinc Binding domain of Nup475/TTP/TIS11===




==Overview==
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Nup475 (also known as tristetraprolin and TIS11) includes two zinc-binding domains of the form Cys-X8-Cys-X5-Cys-X3-His. These domains are required for rapid degradation of tumor necrosis factor (TNF) and other mRNAs through the interaction with AU-rich elements in their 3'-untranslated regions. The three-dimensional solution structure of the first domain was determined by multidimensional nuclear magnetic resonance spectroscopy, revealing a novel fold around a central zinc ion. The core structure is disk-like with a diameter of approximately 25 A and a width of approximately 12 A. This structure provides a basis for evaluating the role of individual residues for structural stability and for nucleic acid binding.
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{{ABSTRACT_PUBMED_12515557}}


==About this Structure==
==About this Structure==
1M9O is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M9O OCA].  
1M9O is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M9O OCA].  


==Reference==
==Reference==
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[[Category: Worthington, M T.]]
[[Category: Worthington, M T.]]
[[Category: Cys3his type zinc finger]]
[[Category: Cys3his type zinc finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:30:28 2008''

Revision as of 20:30, 2 July 2008

File:1m9o.png

Template:STRUCTURE 1m9o

NMR structure of the first Zinc Binding domain of Nup475/TTP/TIS11

Template:ABSTRACT PUBMED 12515557

About this Structure

1M9O is a Single protein structure of sequence from Mus musculus. Full experimental information is available from OCA.

Reference

A Cys3His zinc-binding domain from Nup475/tristetraprolin: a novel fold with a disklike structure., Amann BT, Worthington MT, Berg JM, Biochemistry. 2003 Jan 14;42(1):217-21. PMID:12515557

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